GPBP1 - GC-rich promoter binding protein 1 Gene

中文名称：富 GC 的启动子结合蛋白 1

种属: Homo sapiens

同用名: GPBP; SSH6; VASCULIN

关于 GPBP1

功能概要

该基因最初是通过对在具有血栓的动脉粥样硬化斑块中表达的 cDNA 进行消减杂交而分离出来的，并且发现它仅在血管平滑肌细胞中表达。然而，发现更短的剪接变体更普遍地表达。这种蛋白质被认为在动脉粥样硬化的发展中发挥作用。对小鼠的研究表明，它还可以作为富含 GC 的启动子特异性反式激活转录因子发挥作用。已经针对该基因描述了几种编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 2 月]

This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]