2. Gene
  3. SHLD1 - shieldin complex subunit 1 Gene

SHLD1 - shieldin complex subunit 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：shieldin 复合亚基 1

种属: Homo sapiens

同用名: RINN3; C20orf196

基因 ID: 149840 | 基因类型: protein coding

关于 SHLD1

Cytogenetic location: 20p12.3 Genomic coordinates (GRCh38): 20:5,750,193-5,864,395 (from NCBI)

This gene has 4 transcripts (splice variants) and 107 orthologues. Ubiquitous expression in lymph node (RPKM 1.6), adrenal (RPKM 1.1) and 24 other tissues.

功能概要

通过同源重组参与双链断裂修复的负调控；通过非同源末端连接对双链断裂修复进行正调控；和同种型转换的正向调节。位于双链断裂位点。 [由基因组资源联盟提供，2022 年 4 月]

Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

SHLD1 基因产物(4)

mRNA Protein Name
NM_001303477.2 NP_001290406.1 shieldin complex subunit 1 isoform 1
NM_001303478.2 NP_001290407.1 shieldin complex subunit 1 isoform 2
NM_001303479.2 NP_001290408.1 shieldin complex subunit 1 isoform 3
NM_152504.4 NP_689717.2 shieldin complex subunit 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
29656893 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
29656893 GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining IDA
IDA: 通过直接分析推断
29656893 GOA
involved in positive regulation of isotype switching IDA
IDA: 通过直接分析推断
29656893 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome IDA
IDA: 通过直接分析推断
29656893 GOA
located in site of double-strand break IDA
IDA: 通过直接分析推断
29656893 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SHLD1 蛋白结构

DUF4521

DUF4521: Protein of unknown function (DUF4521) (1 - 204)

  • 0
  • 100
  • 205 a.a.
蛋白主名 其他名称

shieldin complex subunit 1

RINN1-REV7-interacting novel NHEJ regulator 3

SHLD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SHLD1 Q8IYI0 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra SHLD1 Q8IYI0 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra SHLD1 Q8IYI0 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra SHLD1 Q8IYI0 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra SHLD1 Q8IYI0 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra SHLD1 Q8IYI0 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra SHLD1 Q8IYI0 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra SHLD1 Q8IYI0 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra SHLD1 Q8IYI0 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra SHLD1 Q8IYI0 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra SHLD1 Q8IYI0 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra SHLD1 Q8IYI0 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra SHLD1 Q8IYI0 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra SHLD1 Q8IYI0 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra SHLD1 Q8IYI0 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra SHLD1 Q8IYI0 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra SHLD1 Q8IYI0 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra SHLD1 Q8IYI0 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra SHLD1 Q8IYI0 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra SHLD1 Q8IYI0 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra SHLD1 Q8IYI0 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112210 Shield-1 Modulator 99.73% 否
HY-RS12873 SHLD1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SHLD1 VGNC VGNC:49170
Canis familiaris SHLD1 VGNC VGNC:52529
Rattus norvegicus SHLD1 RGD RGD:1597982
Felis catus SHLD1 VGNC VGNC:65127
Mus musculus SHLD1 MGD MGI:1920997
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