1. Gene
  2. GGA1 - golgi associated, gamma adaptin ear containing, ARF binding protein 1 Gene

GGA1 - golgi associated, gamma adaptin ear containing, ARF binding protein 1 Gene

中文名称:含高尔基体相关,伽马适应蛋白耳,ARF 结合蛋白 1

种属: Homo sapiens

基因 ID: 26088 | 基因类型: protein coding

关于 GGA1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,608,834-37,633,564 (from NCBI)

This gene has 23 transcripts (splice variants), 273 orthologues and 10 paralogues. Broad expression in testis (RPKM 36.8), spleen (RPKM 8.3) and 23 other tissues.

功能概要

该基因编码高尔基体本地化的伽马适应蛋白耳含 ARF 结合 (GGA) 蛋白家族的成员。这个家族的成员是无处不在的外壳蛋白,它们调节反式高尔基体网络和溶酶体之间的蛋白质运输。这些蛋白质共享一个氨基末端 VHS 结构域,该结构域介导反式高尔基体网络中甘露糖 6-磷酸受体的分选。它们还包含与伽马适应蛋白的耳结构域同源的羧基末端区域。已为该基因发现编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GGA1 基因产物(5)

mRNA Protein Name
NM_001001560.3 NP_001001560.1 ADP-ribosylation factor-binding protein GGA1 isoform 2
NM_001172687.2 NP_001166158.1 ADP-ribosylation factor-binding protein GGA1 isoform 4
NM_001172688.2 NP_001166159.1 ADP-ribosylation factor-binding protein GGA1 isoform 5
NM_001363771.2 NP_001350700.1 ADP-ribosylation factor-binding protein GGA1 isoform 6
NM_013365.5 NP_037497.1 ADP-ribosylation factor-binding protein GGA1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11387475 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
12668765 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi to plasma membrane protein transport IDA
IDA: 通过直接分析推断
27901063 GOA
involved in intracellular protein transport IDA
IDA: 通过直接分析推断
15886016 GOA
involved in protein localization IDA
IDA: 通过直接分析推断
15886016 GOA
involved in protein localization to cell surface IDA
IDA: 通过直接分析推断
27901063 GOA
involved in retrograde transport, endosome to Golgi IDA
IDA: 通过直接分析推断
15886016 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome IDA
IDA: 通过直接分析推断
15886016 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
12668765 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GGA1 蛋白结构

VHS

VHS: VHS domain (8 - 143)

GAT

GAT: GAT domain (206 - 305)

Alpha_adaptinC2

Alpha_adaptinC2: Adaptin C-terminal domain (514 - 631)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 639 a.a.
蛋白主名 其他名称

ADP-ribosylation factor-binding protein GGA1

ADP-ribosylation factor binding protein 1

GGA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GGA1 Q9UJY5 IGF2R Homo sapiens P11717
Pull Down
11387475
Intra GGA1 Q9UJY5 IGF2R Homo sapiens P11717
Y2H
11387475
Intra GGA1 Q9UJY5 IGF2R Homo sapiens P11717
FPS
37219487
Intra GGA1 Q9UJY5 SORT1 Homo sapiens Q99523
Far-WB
20676133
Intra GGA1 Q9UJY5 SORL1 Homo sapiens Q92673
Pull Down
11821067
Intra GGA1 Q9UJY5 BACE1 Homo sapiens P56817
Anti Tag CoIP
26053850
Intra GGA1 Q9UJY5 GTSE1 Homo sapiens Q9NYZ3
FPS
37219487
Intra GGA1 Q9UJY5 GTSE1 Homo sapiens Q9NYZ3
Phage Display
37219487
Intra GGA1 Q9UJY5 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Intra GGA1 Q9UJY5 MYH9 Homo sapiens P35579
Phage Display
39009827
Intra GGA1 Q9UJY5 MYH9 Homo sapiens P35579
FPS
39009827
Intra GGA1 Q9UJY5 MON2 Homo sapiens Q7Z3U7
Anti Tag CoIP
18418388
Intra GGA1 Q9UJY5 MON2 Homo sapiens Q7Z3U7
Pull Down
18418388
Intra GGA1 Q9UJY5 RNF11 Homo sapiens Q9Y3C5
Y2H
15231748
Intra GGA1 Q9UJY5 RNF11 Homo sapiens Q9Y3C5
FPS
37219487
Intra GGA1 Q9UJY5 RNF11 Homo sapiens Q9Y3C5
Phage Display
37219487
Intra GGA1 Q9UJY5 RNF11 Homo sapiens Q9Y3C5
ITC
37219487
Intra GGA1 Q9UJY5 RNF11 Homo sapiens Q9Y3C5
Far-WB
20676133
Intra GGA1 Q9UJY5 RABEP1 Homo sapiens Q15276
Anti Tag CoIP
12505986
Intra GGA1 Q9UJY5 RABEP1 Homo sapiens Q15276
X-Ray Diffraction
14637142
Intra GGA1 Q9UJY5 RABEP1 Homo sapiens Q15276
Y2H
12505986
Intra GGA1 Q9UJY5 GGA3 Homo sapiens Q9NZ52
Pull Down
14638859
Intra GGA1 Q9UJY5 GGA3 Homo sapiens Q9NZ52
EM
14638859
Intra GGA1 Q9UJY5 GGA2 Homo sapiens Q9UJY4
EM
14638859
Intra GGA1 Q9UJY5 GGA2 Homo sapiens Q9UJY4
Pull Down
14638859
Intra GGA1 Q9UJY5 GGA2 Homo sapiens Q9UJY4
Confocal
14638859
Intra GGA1 Q9UJY5 C1orf216 Homo sapiens Q8TAB5
Y2H Prey Pooling
25416956
Intra GGA1 Q9UJY5 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
25416956
Intra GGA1 Q9UJY5 C1orf216 Homo sapiens Q8TAB5
Y2H Array
25416956
Intra GGA1 Q9UJY5 JUN Homo sapiens P05412
Phage Display
37219487
Intra GGA1 Q9UJY5 JUN Homo sapiens P05412
FPS
37219487
Cross GGA1 Q9UJY5 RABGEF1 Bos taurus O18973
Immunodepletion CoIP
12505986
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus GGA1 VGNC VGNC:29335
Macaca mulatta GGA1 VGNC VGNC:72737
Canis familiaris GGA1 VGNC VGNC:41193
Rattus norvegicus GGA1 RGD RGD:1307770
Mus musculus GGA1 MGD MGI:2146207