GTSE1 - G2 and S-phase expressed 1 Gene

中文名称：G2 和 S 期表示 1

种属: Homo sapiens

同用名: B99

关于 GTSE1

功能概要

该基因编码的蛋白质仅在细胞周期的 S 期和 G2 期表达，与细胞质微管蛋白和微管共定位。为了响应 DNA 损伤，编码的蛋白质在细胞核中积累并结合肿瘤抑制蛋白 p53，将其穿梭出细胞核并抑制其诱导细胞凋亡的能力。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce Apoptosis. [provided by RefSeq, Jul 2008]