GGA2 - golgi associated, gamma adaptin ear containing, ARF binding protein 2 Gene

中文名称：含高尔基体相关，伽马适应蛋白耳，ARF 结合蛋白 2

种属: Homo sapiens

同用名: VEAR

关于 GGA2

功能概要

该基因编码高尔基体本地化的伽马适应蛋白耳含 ARF 结合 (GGA) 家族的成员。这个家族包括无处不在的外壳蛋白，它们调节反式高尔基体网络和溶酶体之间的蛋白质运输。这些蛋白质共享一个氨基末端 VHS 结构域，该结构域介导反式高尔基体网络中甘露糖 6-磷酸受体的分选。它们还包含与伽马适应蛋白的耳结构域同源的羧基末端区域。该家族成员可能在货物分子调节和网格蛋白包被的囊泡组装中发挥重要作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]