GGA3 - golgi associated, gamma adaptin ear containing, ARF binding protein 3 Gene

中文名称：含高尔基体相关，伽马适应蛋白耳，ARF 结合蛋白 3

种属: Homo sapiens

关于 GGA3

功能概要

该基因编码高尔基体本地化的伽马适应蛋白耳含 ARF 结合 (GGA) 家族的成员。这个家族包括无处不在的外壳蛋白，它们调节反式高尔基体网络和溶酶体之间的蛋白质运输。这些蛋白质共享一个氨基末端 VHS 结构域，该结构域介导反式高尔基体网络中甘露糖 6-磷酸受体的分选。它们还包含与伽马适应蛋白的耳结构域同源的羧基末端区域。已在该基因中鉴定出多个选择性剪接的转录物变体。[RefSeq 提供，2010 年 2 月]

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]