PTGDR - prostaglandin D2 receptor Gene

中文名称：前列腺素 D2 受体

种属: Homo sapiens

同用名: DP; AS1; DP1; ASRT1; PTGDR1

基因 ID: 5729 | 基因类型: protein coding

关于 PTGDR

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:52,267,698-52,280,914 (from NCBI)

This gene has 2 transcripts (splice variants), 117 orthologues, 7 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 1.6), colon (RPKM 1.3) and 19 other tissues.

功能概要

该基因编码鸟嘌呤核苷酸结合蛋白 (G 蛋白) 偶联受体 (GPCR) 超家族的成员。这些受体是七次跨膜蛋白，可响应细胞外信号并激活细胞内信号转导通路。据报道，这种蛋白质是前列腺素 D2 的受体，前列腺素 D2 是哮喘中过敏性炎症和过敏性气道炎症的介质。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PTGDR 基因产物(3)

mRNA	Protein	Name
NM_001281469.2	NP_001268398.1	prostaglandin D2 receptor isoform 2
NM_000953.3	NP_000944.1	prostaglandin D2 receptor isoform 1
XM_005267891.5	XP_005267948.1	prostaglandin D2 receptor isoform X1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	20959461	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	20959461	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTGDR 蛋白结构

7tm_1

0
100
200
300
359 a.a.

蛋白主名

其他名称

prostaglandin D2 receptor

PGD2 receptor

PTGDR 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PTGDR	Q13258	GGA3	Homo sapiens	Q9NZ52	Pull Down	32334026

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Anemia Of Prematurity

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Retinitis Pigmentosa 11

RP11	Retinitis Pigmentosa-11
Retinitis Pigmentosa, Type 11

Spermatogenic Failure 24

SPGF24

Spermatogenic Failure, Type 24

Asthma-Related Traits 1

Asthma-Related Traits, Susceptibility To, 1	ASRT1
Asthma, Susceptibility To, 1	As1
Asthma 1	Asthma-Related Traits, Susceptibility To, Type 1

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11368	PTGDR Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11369	Ptgdr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11370	PTGDR Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11371	PTGDR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11372	Ptgdr2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11373	Ptgdr2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PTGDR	RGD	RGD:619707
Bos taurus	PTGDR	VGNC	VGNC:33499
Mus musculus	PTGDR	MGD	MGI:102966
Macaca mulatta	PTGDR	VGNC	VGNC:76467
Canis familiaris	PTGDR	VGNC	VGNC:45140

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