ARF6 - ADP ribosylation factor 6 Gene

中文名称：ADP 核糖基化因子 6

种属: Homo sapiens

基因 ID: 382 | 基因类型: protein coding

关于 ARF6

Cytogenetic location: 14q21.3 Genomic coordinates (GRCh38): 14:49,893,082-49,897,054 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 30 paralogues. Ubiquitous expression in esophagus (RPKM 54.5), colon (RPKM 38.8) and 25 other tissues.

功能概要

该基因编码人类 ARF 基因家族的一个成员，该家族是 Ras 超家族的一部分。 ARF 基因编码小鸟嘌呤核苷酸结合蛋白，可刺激霍乱毒素的 ADP-核糖基转移酶活性，并在水泡运输中发挥作用，并作为磷脂酶 D 的激活剂。该基因的产物定位于质膜，并调节水泡运输，膜脂重塑，以及导致肌动蛋白重塑的信号通路。该基因的假基因位于 7 号染色体上。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the human ARF gene family, which is part of the Ras superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of Phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]

ARF6 基因产物(1)

mRNA	Protein	Name
NM_001663.4	NP_001654.1	ADP-ribosylation factor 6

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein activity	IDA IDA: 通过直接分析推断	32103017	GOA
enables GDP binding	IDA IDA: 通过直接分析推断	15126638	GOA
enables GTP binding	IDA IDA: 通过直接分析推断	10391955	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9312003	GOA
enables signaling adaptor activity	IDA IDA: 通过直接分析推断	37461827	GOA
enables thioesterase binding	IPI IPI: 通过物理相互作用推断	15509780	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cortical actin cytoskeleton organization	IDA IDA: 通过直接分析推断	10036235	GOA
involved in cortical actin cytoskeleton organization	IMP IMP: 通过突变表型推断	10913182	GOA
involved in endocytic recycling	IDA IDA: 通过直接分析推断	10036235	GOA
involved in positive regulation of actin filament polymerization	IMP IMP: 通过突变表型推断	10036235	GOA
involved in positive regulation of mitotic cytokinetic process	IMP IMP: 通过突变表型推断	17628206	GOA
involved in positive regulation of neuron projection development	IDA IDA: 通过直接分析推断	36250347	GOA
involved in positive regulation of protein secretion	IMP IMP: 通过突变表型推断	27044754	GOA
involved in protein localization to cleavage furrow	IMP IMP: 通过突变表型推断	16148947	GOA
involved in protein localization to endosome	IMP IMP: 通过突变表型推断	21951725	GOA
involved in protein localization to plasma membrane	IDA IDA: 通过直接分析推断	37461827	GOA
involved in regulation of Rac protein signal transduction	IDA IDA: 通过直接分析推断	10036235	GOA
involved in regulation of filopodium assembly	IDA IDA: 通过直接分析推断	14978216	GOA
involved in ruffle assembly	IDA IDA: 通过直接分析推断	10036235	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Flemming body	IDA IDA: 通过直接分析推断	23603394	GOA
located in cell cortex	IDA IDA: 通过直接分析推断	10913182	GOA
located in cleavage furrow	IDA IDA: 通过直接分析推断	23603394	GOA
is active in cleavage furrow	IMP IMP: 通过突变表型推断	16148947	GOA
is active in cytosol	IDA IDA: 通过直接分析推断	32103017	GOA
located in cytosol	IDA IDA: 通过直接分析推断	10391955	GOA
located in endocytic vesicle	IDA IDA: 通过直接分析推断	19948740	GOA
located in endosome	IDA IDA: 通过直接分析推断	20682791	GOA
located in filopodium membrane	IDA IDA: 通过直接分析推断	14978216	GOA
located in membrane	IDA IDA: 通过直接分析推断	10391955	GOA
is active in midbody	IMP IMP: 通过突变表型推断	16148947	GOA
is active in plasma membrane	IDA IDA: 通过直接分析推断	32103017	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	10036235	GOA
located in recycling endosome membrane	IDA IDA: 通过直接分析推断	10036235	GOA
located in ruffle	IDA IDA: 通过直接分析推断	9312003	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARF6 蛋白结构

Arf

0
100
175 a.a.

蛋白主名

其他名称

ADP-ribosylation factor 6

ARF6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ARF6	P62330	SPAG9	Homo sapiens	O60271	SPR	19644450
Intra	ARF6	P62330	SPAG9	Homo sapiens	O60271	Solution Sedimentation	19644450
Intra	ARF6	P62330	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ARF6	P62330	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ARF6	P62330	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Cross	ARF6	P62330	P0DTD1-PRO_0000449632	SARS-CoV-2	P0DTD1-PRO_0000449632	Y2H Array	36217030
Intra	ARF6	P62330	KIF23	Homo sapiens	Q02241	Y2H	22580824
Intra	ARF6	P62330	KIF23	Homo sapiens	Q02241	Pull Down	22580824
Intra	ARF6	P62330	GGA3	Homo sapiens	Q9NZ52	Pull Down	24056087
Intra	ARF6	P62330	ARFIP2	Homo sapiens	P53365	Y2H	9312003
Intra	ARF6	P62330	ARFIP2	Homo sapiens	P53365	Beta Galactosidase	9312003
Intra	ARF6	P62330	APBB1	Homo sapiens	O00213	Pull Down	24056087
Intra	ARF6	P62330	APBB1	Homo sapiens	O00213	Anti Tag CoIP	24056087
Intra	ARF6	P62330	ATP6V1C1	Homo sapiens	P21283	Anti Bait CoIP	16415858

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome

Door Syndrome	Doors Syndrome
Digitorenocerebral Syndrome	Autosomal Recessive Deafness-Onychodystrophy Syndrome
Deafness-Onychoosteodystrophy-Intellectual Disability Syndrome	DOORS
Drc Syndrome	Eronen Syndrome
Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Brachydactyly Due To Absence Of Distal Phalanges
Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome	Deafness, Onychodystrophy, Osteodystrophy, And Mental Retardation Syndrome
Deafness-Oncychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Autosomal Recessive Hearing Loss-Onychodystrophy Syndrome
Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome
Hearing Loss-Onychoosteodystrophy-Intellectual Disability Syndrome	Deafness, Onychodystrophy, Osteodystrophy, Intellectual Disability, And Seizures Syndrome
Deafness, Congenital Onychodystrophy, Recessive Form	Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation Syndrome

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-112473	NAV-2729	Inhibitor	98.57%	否
HY-139950	Rasarfin	Inhibitor	99.57%	否
HY-RS00898	ARF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	ARF6	VGNC	VGNC:26061
Macaca mulatta	ARF6	VGNC	VGNC:84306
Mus musculus	ARF6	MGD	MGI:99435
Canis familiaris	ARF6	VGNC	VGNC:38031
Felis catus	ARF6	VGNC	VGNC:68044
Rattus norvegicus	ARF6	RGD	RGD:621279

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