2. Gene
  3. SPAG9 - sperm associated antigen 9 Gene

SPAG9 - sperm associated antigen 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：精子相关抗原 9

种属: Homo sapiens

同用名: JLP; CT89; HLC4; HLC6; JIP4; PHET; PIG6; HLC-6; JIP-4

基因 ID: 9043 | 基因类型: protein coding

关于 SPAG9

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,962,174-51,120,868 (from NCBI)

This gene has 21 transcripts (splice variants), 289 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 29.0), testis (RPKM 27.0) and 25 other tissues.

功能概要

该基因编码癌症睾丸抗原基因家族的成员。编码的蛋白质充当支架蛋白，在结构上组织丝裂原活化蛋白激酶并介导 c-Jun 末端激酶信号传导。这种蛋白质还与驱动蛋白 1 结合，并可能参与基于微管的膜转运。这种蛋白质可能在肿瘤的生长和发展中发挥作用。交替剪接导致多个转录本变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a member of the Cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

SPAG9 基因产物(4)

mRNA Protein Name
NM_001130527.3 NP_001123999.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 2
NM_001130528.3 NP_001124000.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 1
NM_001251971.2 NP_001238900.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 4
NM_003971.6 NP_003962.3 C-Jun-amino-terminal kinase-interacting protein 4 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19644450 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lysosome localization IMP
IMP: 通过突变表型推断
29146937 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
18826971 GOA
acts upstream of or within retrograde transport, endosome to Golgi IDA
IDA: 通过直接分析推断
19056739 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lysosomal membrane IDA
IDA: 通过直接分析推断
29146937 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPAG9 蛋白结构

Jnk-SapK_ap_N

Jnk-SapK_ap_N: JNK_SAPK-associated protein-1 (24 - 180)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1321 a.a.
蛋白主名 其他名称

C-Jun-amino-terminal kinase-interacting protein 4

JNK interacting protein

SPAG9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SPAG9 O60271 EXOC4 Homo sapiens Q96A65
Anti Bait CoIP
25244576
Intra SPAG9 O60271 EXOC4 Homo sapiens Q96A65
Anti Tag CoIP
25244576
Intra SPAG9 O60271 ARF6 Homo sapiens P62330
X-Ray Diffraction
19644450
Intra SPAG9 O60271 ARF6 Homo sapiens P62330
Solution Sedimentation
19644450
Intra SPAG9 O60271 ARF6 Homo sapiens P62330
SPR
19644450
Cross SPAG9 O60271 Arf6 Mus musculus P62331
Pull Down
22522702
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Infertility
Retinitis Pigmentosa 42

RP42

Retinitis Pigmentosa-42

Retinitis Pigmentosa, Type 42
Subacute Leukemia
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13627 SPAG9 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SPAG9 VGNC VGNC:35170
Mus musculus SPAG9 MGD MGI:1918084
Felis catus SPAG9 VGNC VGNC:65599
Rattus norvegicus SPAG9 RGD RGD:1311289
Canis familiaris SPAG9 VGNC VGNC:46699
Macaca mulatta SPAG9 VGNC VGNC:77920
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