ATP6V1C1 - ATPase H+ transporting V1 subunit C1 Gene

中文名称：ATPase H+ 转运 V1 亚基 C1

种属: Homo sapiens

同用名: VATC; Vma5; ATP6C; ATP6D

关于 ATP6V1C1

功能概要

该基因编码液泡 ATP 酶 (V-ATPase) 的一个组分，这是一种多亚基酶，可介导真核细胞胞内区室的酸化。 V-ATPase 依赖性酸化对于蛋白质分选、酶原激活、受体介导的内吞作用和突触小泡质子梯度生成等细胞内过程是必需的。 V-ATPase 由胞质 V1 结构域和跨膜 V0 结构域组成。 V1 结构域由三个 A 和三个 B 亚基、两个 G 亚基以及 C、D、E、F 和 H 亚基组成。 V1 域包含 ATP 催化位点。 V0 结构域由五个不同的亚基组成：a、c、c'、c'' 和 d。许多 V1 和 V0 亚基蛋白的其他亚型由多个基因或剪接的转录变体编码。该基因是编码 V1 结构域 C 亚基蛋白的两个基因之一，普遍存在。此 C 亚基与 F-ATP 酶的 γ 亚基类似但不同源。以前，该基因被命名为 ATP6D。[RefSeq 提供，2008 年 7 月]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit Enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008]