CLIP3 - CAP-Gly domain containing linker protein 3 Gene

中文名称：含 CAP-Gly 结构域的连接蛋白 3

种属: Homo sapiens

同用名: RSNL1; CLIPR59; CLIPR-59

关于 CLIP3

功能概要

该基因编码细胞质连接蛋白 170 家族的成员。该蛋白质家族的成员包含一个细胞骨架相关蛋白富含甘氨酸的结构域，并介导微管与细胞器的相互作用。编码的蛋白质通过促进微管蛋白与脂筏神经节苷脂 GD3 的结合而在 T 细胞凋亡中发挥作用。编码的蛋白质还充当支架蛋白，介导磷酸化蛋白激酶 B 的膜定位。已经观察到该基因的选择性剪接转录变体。[RefSeq 提供，2010 年 12 月]

This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell Apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]