UBE2E3 - ubiquitin conjugating enzyme E2 E3 Gene

中文名称：泛素结合酶 E2 E3

种属: Homo sapiens

同用名: UBCH9; UbcM2

关于 UBE2E3

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。编码的蛋白质与小鼠和大鼠对应物具有 100% 的序列同一性，这表明该酶在真核生物中高度保守。已为该基因发现了编码相同蛋白质的多个可变剪接转录物变体。[RefSeq 提供，2013 年 6 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this Enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]