1. Gene
  2. TRIM62 - tripartite motif containing 62 Gene

TRIM62 - tripartite motif containing 62 Gene

中文名称:含三方基序 62

种属: Homo sapiens

同用名: DEAR1

基因 ID: 55223 | 基因类型: protein coding

关于 TRIM62

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:33,145,399-33,182,043 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 80 paralogues. Ubiquitous expression in skin (RPKM 2.0), brain (RPKM 1.3) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性;转录共激活因子活性;和泛素蛋白转移酶活性。参与多个过程,包括病毒转录的负调控; NF-kappaB 转录因子活性的正调控;和抗真菌先天免疫反应的积极调节。在细胞质中有活性。 [由基因组资源联盟提供,2022 年 4 月]

Enables identical protein binding activity; transcription coactivator activity; and ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of viral transcription; positive regulation of NF-kappaB transcription factor activity; and positive regulation of Antifungal innate immune response. Is active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TRIM62 基因产物(2)

mRNA Protein Name
NM_001330483.2 NP_001317412.1 E3 ubiquitin-protein ligase TRIM62 isoform 2
NM_018207.3 NP_060677.2 E3 ubiquitin-protein ligase TRIM62 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
23077300 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
26488816 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
23402750 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
26488816 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
23402750 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRIM62 蛋白结构

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (11 - 53)

zf-B_box

zf-B_box: B-box zinc finger (90 - 126)

PRY

PRY: SPRY-associated domain (297 - 346)

SPRY

SPRY: SPRY domain (348 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 475 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase TRIM62

RING-type E3 ubiquitin transferase TRIM62

TRIM62 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TRIM62 Q9BVG3 SP7 Homo sapiens Q8TDD2
Y2H Array
32296183
Intra TRIM62 Q9BVG3 SP7 Homo sapiens Q8TDD2
Y2H Prey Pooling
32296183
Intra TRIM62 Q9BVG3 FAIM Homo sapiens Q9NVQ4-2
Validated Y2H
32296183
Intra TRIM62 Q9BVG3 EPN2 Homo sapiens O95208-2
Y2H Prey Pooling
32296183
Intra TRIM62 Q9BVG3 EPN2 Homo sapiens O95208-2
Y2H Array
32296183
Intra TRIM62 Q9BVG3 TBC1D7 Homo sapiens Q9P0N9
Validated Y2H
32296183
Intra TRIM62 Q9BVG3 EXOSC5 Homo sapiens Q9NQT4
Validated Y2H
32296183
Intra TRIM62 Q9BVG3 TRIM62 Homo sapiens Q9BVG3
Validated Y2H
32296183
Intra TRIM62 Q9BVG3 TRIM62 Homo sapiens Q9BVG3
Complementation
32296183
Intra TRIM62 Q9BVG3 TRIM62 Homo sapiens Q9BVG3
MAPPIT
32296183
Intra TRIM62 Q9BVG3 TRIM62 Homo sapiens Q9BVG3
Y2H Prey Pooling
32296183
Intra TRIM62 Q9BVG3 TRIM62 Homo sapiens Q9BVG3
Y2H Array
32296183
Intra TRIM62 Q9BVG3 UBE2D4 Homo sapiens Q9Y2X8
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ring Chromosome 1

Chromosome 1 Ring

R1

Ring 1

Ring Chromosome 1 Syndrome

R(1) Syndrome

Ring Chromosome
Immunodeficiency 27b

Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency

IMD27B

Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant

Ifngr1 Deficiency, Autosomal Dominant

Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency

Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency

Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency

Immunodeficiency 27b, Mycobacteriosis, Ad

Autosomal Dominant Ifngr1 Deficiency

Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis

Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant

Immunodeficiency 27a

IMD27A

Autosomal Recessive Ifngr1 Deficiency

Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency

Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency

Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency

Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive

Ifngr1 Deficiency, Autosomal Recessive

Immunodeficiency 27a, Mycobacteriosis, Ar

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency

Msmd Due To Complete Ifngammar1 Deficiency

Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency

Familial Disseminated Atypical Mycobacterial Infection

Interferon Gamma, Receptor 1, Deficiency

Immunodeficiency, Type 27a, Mycobacteriosis, Ar

Mycobacterial Disease, Mendelian Susceptibility To

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus TRIM62 VGNC VGNC:66547
Mus musculus TRIM62 MGD MGI:1914775
Macaca mulatta TRIM62 VGNC VGNC:79513
Bos taurus TRIM62 VGNC VGNC:36345
Rattus norvegicus TRIM62 RGD RGD:1586169
Canis familiaris TRIM62 VGNC VGNC:47830