1. 重组蛋白
  2. Cytokines and Growth Factors
  3. EGF Superfamily
  4. TGF-alpha

TGF-alpha  (转化生长因子α)

转化生长因子α (TGF-alpha; TGF-α) 是一种有丝分裂多肽,属于表皮生长因子超家族细胞因子。TGF-α 由 50 个氨基酸组成,与 EGF 具有35-40%的同源性,EGF是EGF超家族的原型成员。和 EGF一样,TGF-α 也是表皮生长因子受体 (EGFR) 的配体。TGF-α 与 EGFR 结合,刺激完整的 RAS/RAF/MAPK 通路,导致与细胞增殖、侵袭和转移相关基因的转录。

Transforming growth factor α (TGF-alpha; TGF-α) is a mitogenic polypeptide member of the epidermal growth factor (EGF) family of cytokines. TGF-α is composed of 50 amino acids, and displays 35-40% homology with EGF which is the prototypic member of the EGF superfamily. Like EGF, TGF-α is also a ligand of epidermal growth factor receptor (EGFR). TGF-α binds to the EGFR to stimulate an intact RAS/RAF/MAPK pathway, leading to the transcription of genes associated with cell proliferation, invasion and metastasis.

目录号 产品名 / 同用名 种属 表达系统
目录号 产品名 作用方式 纯度