1. Gene
  2. WDR74 - WD repeat domain 74 Gene

WDR74 - WD repeat domain 74 Gene

中文名称:WD 重复域 74

种属: Homo sapiens

同用名: Nsa1

基因 ID: 54663 | 基因类型: protein coding

关于 WDR74

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,832,905-62,841,809 (from NCBI)

This gene has 17 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in bone marrow (RPKM 9.1), ovary (RPKM 4.9) and 25 other tissues.

功能概要

参与 rRNA 加工和核糖体大亚基生物合成。位于核质中。与核外泌体 (RNase 复合物) 和核仁共定位。 [由基因组资源联盟提供,2022 年 4 月]

Involved in rRNA processing and ribosomal large subunit biogenesis. Located in nucleoplasm. Colocalizes with nuclear exosome (RNase complex) and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

WDR74 基因产物(8)

mRNA Protein Name
NM_001307977.1 NP_001294906.1 WD repeat-containing protein 74 isoform 2
NM_001369447.1 NP_001356376.1 WD repeat-containing protein 74 isoform 3
NM_001369448.1 NP_001356377.1 WD repeat-containing protein 74 isoform 4
NM_001369449.1 NP_001356378.1 WD repeat-containing protein 74 isoform 4
NM_001369450.1 NP_001356379.1 WD repeat-containing protein 74 isoform 1
NM_001369451.1 NP_001356380.1 WD repeat-containing protein 74 isoform 1
NM_001369453.1 NP_001356382.1 WD repeat-containing protein 74 isoform 1
NM_018093.3 NP_060563.2 WD repeat-containing protein 74 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in rRNA processing IMP
IMP: 通过突变表型推断
29107693 GOA
involved in ribosomal large subunit biogenesis IMP
IMP: 通过突变表型推断
26456651 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of nuclear exosome (RNase complex) IDA
IDA: 通过直接分析推断
26456651 GOA
colocalizes with nucleolus IDA
IDA: 通过直接分析推断
26456651 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
12429849 GOA
located in nucleolus IMP
IMP: 通过突变表型推断
29107693 GOA
located in nucleus IDA
IDA: 通过直接分析推断
28416111 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

WDR74 蛋白结构

WD40

WD40: WD domain, G-beta repeat (269 - 295)

  • 0
  • 100
  • 200
  • 300
  • 385 a.a.
蛋白主名 其他名称

WD repeat-containing protein 74

NOP seven-associated protein 1

WDR74 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra WDR74 Q6RFH5 RCHY1 Homo sapiens Q96PM5
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lateral Ventricle Meningioma

Meningioma Of The Lateral Ventricle

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris WDR74 VGNC VGNC:48386
Felis catus WDR74 VGNC VGNC:67053
Bos taurus WDR74 VGNC VGNC:36918
Rattus norvegicus WDR74 RGD RGD:1582881
Macaca mulatta WDR74 VGNC VGNC:79509
Mus musculus WDR74 MGD MGI:2147427