2. Gene
  3. ARF4 - ADP ribosylation factor 4 Gene

ARF4 - ADP ribosylation factor 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ADP 核糖基化因子 4

种属: Homo sapiens

同用名: ARF2

基因 ID: 378 | 基因类型: protein coding

关于 ARF4

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:57,571,363-57,597,344 (from NCBI)

This gene has 9 transcripts (splice variants), 147 orthologues and 30 paralogues. Ubiquitous expression in gall bladder (RPKM 100.9), placenta (RPKM 94.0) and 25 other tissues.

功能概要

该基因是人类 ARF 基因家族的成员，其成员编码小的鸟嘌呤核苷酸结合蛋白，可刺激霍乱毒素的 ADP-核糖基转移酶活性，并在水泡运输中发挥作用，并作为磷脂酶 D 的激活剂。基因产物包括 5 ARF 蛋白质和 11 种 ARF 样蛋白质，构成 Ras 超家族的一个家族。 ARF 蛋白分为 I 类、II 类和 III 类；该基因是 II 类成员。每个班级的成员都有一个共同的基因组织。 ARF4 基因跨度约 12kb，包含六个外显子和五个内含子。该基因是人类 ARF 中差异最大的成员。据报道，该基因在 3p14 或 3p21 的图谱位置存在冲突。[RefSeq 提供，2008 年 7 月]

This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of Phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the Ras superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]

ARF4 基因产物(1)

mRNA Protein Name
NM_001660.4 NP_001651.1 ADP-ribosylation factor 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP binding IDA
IDA: 通过直接分析推断
12446727 GOA
enables NAD+-protein-arginine ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
1899243 GOA
enables epidermal growth factor receptor binding IDA
IDA: 通过直接分析推断
12446727 GOA
enables phospholipase D activator activity IDA
IDA: 通过直接分析推断
12446727 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17956946 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell migration IDA
IDA: 通过直接分析推断
22004728 GOA
acts upstream of or within dendritic spine development IDA
IDA: 通过直接分析推断
23050017 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
19041174 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12446727 GOA
involved in regulation of cilium assembly IDA
IDA: 通过直接分析推断
25673879 GOA
involved in regulation of reactive oxygen species metabolic process IDA
IDA: 通过直接分析推断
19041174 GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IGI
IGI: 通过遗传相互作用推断
24768165 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
25673879 GOA
located in cytosol IDA
IDA: 通过直接分析推断
12446727 GOA
located in dendritic spine IDA
IDA: 通过直接分析推断
23050017 GOA
located in ruffle membrane IDA
IDA: 通过直接分析推断
12446727 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARF4 蛋白结构

Arf

Arf: ADP-ribosylation factor family (6 - 176)

  • 0
  • 100
  • 180 a.a.
蛋白主名 其他名称

ADP-ribosylation factor 4

ADP-ribosylation factor 2

ARF4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ARF4 P18085 COPS3 Homo sapiens Q9UNS2
Validated Y2H
32296183
种属内
ARF4 P18085 COPS3 Homo sapiens Q9UNS2
Y2H Prey Pooling
32296183
种属内
ARF4 P18085 COPS3 Homo sapiens Q9UNS2
Y2H Array
32296183
种属内
ARF4 P18085 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
25416956
种属内
ARF4 P18085 SDCBP2 Homo sapiens Q9H190
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cholera

Vibrio Cholerae Infection

Cholera - Vibrio Cholerae

Cholera Due To Vibrio Cholerae

Vibrio Cholerae

Cholera Syndrome

Asiatic Cholera

Epidemic Cholera
Chromosome 17q21.31 Duplication Syndrome

17q21.31 Microduplication Syndrome

Trisomy 17q21.31

Dup(17)(Q21.31)
Retinitis Pigmentosa 7

Leber Congenital Amaurosis 18

RP7

Retinitis Pigmentosa 7, Digenic Form

Retinitis Pigmentosa 7 And Digenic Form

Retinitis Pigmentosa 7, Digenic

LCA18

Retinitis Pigmentosa 7 Digenic
Retinitis Pigmentosa 2

RP2

X-Linked Retinitis Pigmentosa 2

Xlrp2

Xlrp-2

Retinitis Pigmentosa-2

Retinitis Pigmentosa, Type 2
Periventricular Nodular Heterotopia

Periventricular Heterotopia

Pvnh

Familial Nodular Heterotopia

Heterotopia, Periventricular

Periventricular Heterotopia, X-Linked
Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type

Adpkd

Polycystic Kidney Diseases

Polycystic Kidney, Autosomal Dominant

Congenital Biliary Ectasias

Polycystic Kidney And Hepatic Disease 1

Polycystic Kidney Disease, Autosomal Dominant

Kidney, Polycystic, Disease, Autosomal Dominant

Adult Polycystic Kidney Disease

Polycystic Kidney, Adult Type

Apckd - [Autosomal Polycystic Kidney Disease]
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00896 ARF4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ARF4 VGNC VGNC:26059
Canis familiaris ARF4 VGNC VGNC:38030
Rattus norvegicus ARF4 RGD RGD:621275
Mus musculus ARF4 MGD MGI:99433
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