2. Gene
  3. HRG - histidine rich glycoprotein Gene

HRG - histidine rich glycoprotein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富组氨酸的糖蛋白

种属: Homo sapiens

同用名: HPRG; HRGP; THPH11

基因 ID: 3273 | 基因类型: protein coding

关于 HRG

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,666,014-186,678,234 (from NCBI)

This gene has 3 transcripts (splice variants), 118 orthologues, 3 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 1677.7).

功能概要

这种富含组氨酸的糖蛋白包含两个胱抑素样结构域，位于血浆和血小板中。生理功能尚未确定，但已知该蛋白质可结合血红素、染料和二价金属离子。编码的蛋白质还具有一种肽，该肽对白色念珠菌、大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌和粪肠球菌显示出抗菌活性。它可以抑制玫瑰花结形成并与肝素、血小板反应蛋白和纤溶酶原相互作用。蛋白质的两种作用，纤维蛋白溶解的抑制和凝血抑制的减少，表明潜在的促血栓形成作用。由于富含组氨酸的糖蛋白水平异常，该基因的突变会导致血栓形成倾向。[RefSeq 提供，2014 年 11 月]

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014]

HRG 基因产物(1)

mRNA Protein Name
NM_000412.5 NP_000403.1 histidine-rich glycoprotein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heme binding IDA
IDA: 通过直接分析推断
678554 GOA
enables heparan sulfate proteoglycan binding IDA
IDA: 通过直接分析推断
15138272 GOA
enables heparin binding IDA
IDA: 通过直接分析推断
16436387 GOA
enables immunoglobulin binding IDA
IDA: 通过直接分析推断
10514432 GOA
enables metal ion binding IDA
IDA: 通过直接分析推断
678554 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11134179 GOA
enables signaling receptor binding IDA
IDA: 通过直接分析推断
16436387 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
15138272 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: 通过直接分析推断
18797515 GOA
involved in cytolysis by host of symbiont cells IDA
IDA: 通过直接分析推断
18797515 GOA
involved in defense response to fungus IDA
IDA: 通过直接分析推断
18797515 GOA
involved in negative regulation of angiogenesis IDA
IDA: 通过直接分析推断
14744774 GOA
involved in negative regulation of cell adhesion IDA
IDA: 通过直接分析推断
14744774 GOA
involved in negative regulation of cell adhesion mediated by integrin IDA
IDA: 通过直接分析推断
16489009 GOA
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
21215706 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
14744774 GOA
involved in negative regulation of endothelial cell chemotaxis IDA
IDA: 通过直接分析推断
14744774 GOA
involved in negative regulation of lamellipodium assembly IDA
IDA: 通过直接分析推断
16489009 GOA
involved in negative regulation of vascular endothelial growth factor signaling pathway IDA
IDA: 通过直接分析推断
16489009 GOA
involved in platelet activation IDA
IDA: 通过直接分析推断
19903770 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
14744774 GOA
involved in positive regulation of blood vessel remodeling IDA
IDA: 通过直接分析推断
21215706 GOA
involved in positive regulation of focal adhesion assembly IDA
IDA: 通过直接分析推断
14744774 GOA
involved in positive regulation of immune response to tumor cell IDA
IDA: 通过直接分析推断
21215706 GOA
involved in regulation of actin cytoskeleton organization IDA
IDA: 通过直接分析推断
16489009 GOA
involved in regulation of blood coagulation IDA
IDA: 通过直接分析推断
6740558 GOA
involved in regulation of gene expression IDA
IDA: 通过直接分析推断
21215706 GOA
involved in regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
16489009 GOA
involved in regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
16489009 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
15220341 GOA
located in extracellular region IDA
IDA: 通过直接分析推断
18797515 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HRG 蛋白结构

Cystatin

Cystatin: Cystatin domain (23 - 95)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 525 a.a.
蛋白主名 其他名称

histidine-rich glycoprotein

histidine-proline-rich glycoprotein

HRG 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra HRG P04196 RGS20 Homo sapiens O76081-6
Y2H Prey Pooling
32296183
Intra HRG P04196 RGS20 Homo sapiens O76081-6
Y2H Array
32296183
Intra HRG P04196 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra HRG P04196 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Cross HRG P04196 q99xu0_strp1 Streptococcus pyogenes serotype M1 Q99XU0
ITC
24825900
Intra HRG P04196 RCHY1 Homo sapiens Q96PM5
Confocal
21988832
Intra HRG P04196 RCHY1 Homo sapiens Q96PM5
Y2H
21988832
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HRG 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77380 HPRG Protein, Human (HEK293, His) P04196/NP_000403.1 (V19-K525) ≥95%

关联疾病

疾病名称 别名
Thrombophilia Due To Histidine-Rich Glycoprotein Deficiency

THPH11

Thrombophilia 11 Due To Hrg Deficiency
Thrombophilia Due To Hrg Deficiency

Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency

Hereditary Thrombophilia Due To Congenital Hrg Deficiency

Thph11
Thrombophilia

Hypercoagulability State
Protein C Deficiency

Hereditary Thrombophilia Due To Protein C Deficiency

Proc Deficiency

Congenital Thrombotic Disease, Due To Protein C Deficiency
Thrombosis

Thrombosis Of Blood Vessel
Prothrombin Thrombophilia

Prothrombin G20210a Thrombophilia

Hyperprothrombinemia
Thrombophilia Due To Thrombin Defect

Venous Thromboembolism

Venous Thrombosis

Thrombophilia Due To Factor 2 Defect

Thromboembolism

THPH1

Thromboembolism, Susceptibility To

Venous Thromboembolism, Susceptibility To

Venous Thrombosis, Protection Against

Prothrombin-Related Thrombophilia

Hyperprothrombinemia

Venous Thrombosis, Susceptibility To

Thrombophilia 1 Due To Thrombin Defect

F2-Related Thrombophilia

Factor Ii-Related Thrombophilia

Prothrombin 20210g>A Thrombophilia

Prothrombin G20210a Thrombophilia

Prothrombin Thrombophilia
Corneal Neovascularization

Corneal Neovascularisation

Corneal Vascularisation

Extensive Superficial Corneal Vascularisation
Plasminogen Deficiency, Type I

Hypoplasminogenemia

Dysplasminogenemia

Plasminogen Deficiency Type I

Congenital Plasminogen Deficiency

Ligneous Conjunctivitis

Type 1 Plasminogen Deficiency

Plasminogen Deficiency Type 1

Plasminogen Deficiency

PLGD

Plasminogen Deficiency Type Ii

Deficiency, Plasminogen, Type I
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06358 HRG Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HRG MGD MGI:2146636
Rattus norvegicus HRG RGD RGD:619808
Macaca mulatta HRG VGNC VGNC:73521
Canis familiaris HRG VGNC VGNC:41785
Felis catus HRG VGNC VGNC:67648
Bos taurus HRG VGNC VGNC:29953
Others HRG NCBI
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