GSDMD - gasdermin D Gene

中文名称：gasdermin D

种属: Homo sapiens

同用名: DF5L; DFNA5L; FKSG10; GSDMDC1

基因 ID: 79792 | 基因类型: protein coding

关于 GSDMD

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,553,387-143,563,062 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 187 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 35.6), duodenum (RPKM 18.8) and 24 other tissues.

功能概要

Gasdermin D 是 gasdermin 家族的一员。该家族的成员似乎在调节上皮增殖中发挥作用。 Gasdermin D 已被建议充当肿瘤抑制因子。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2009 年 10 月]

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

GSDMD 基因产物(2)

mRNA	Protein	Name
NM_001166237.1	NP_001159709.1	gasdermin-D
NM_024736.7	NP_079012.3	gasdermin-D

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: 通过直接分析推断	27281216	GOA
enables phosphatidylinositol-4-phosphate binding	IDA IDA: 通过直接分析推断	36227980	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables wide pore channel activity	IDA IDA: 通过直接分析推断	32109412	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of inflammatory response	IDA IDA: 通过直接分析推断	32109412	GOA
involved in positive regulation of interleukin-1 production	IDA IDA: 通过直接分析推断	33883744	GOA
involved in positive regulation of interleukin-18 production	IDA IDA: 通过直接分析推断	33883744	GOA
involved in protein homooligomerization	IDA IDA: 通过直接分析推断	33883744	GOA
involved in protein secretion	IDA IDA: 通过直接分析推断	33883744	GOA
involved in pyroptotic cell death	IDA IDA: 通过直接分析推断	32109412	GOA
involved in pyroptotic inflammatory response	IDA IDA: 通过直接分析推断	28392147	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in membrane	IDA IDA: 通过直接分析推断	32109412	GOA
is active in plasma membrane	IDA IDA: 通过直接分析推断	32109412	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	33883744	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GSDMD 蛋白结构

Gasdermin

0
100
200
300
400
484 a.a.

蛋白主名

其他名称

gasdermin-D

gasdermin domain containing 1

GSDMD 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	GSDMD	P57764	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	GSDMD	P57764	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	GSDMD	P57764	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ASPG	Homo sapiens	Q86U10	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ASPG	Homo sapiens	Q86U10	Validated Y2H	32296183
Intra	GSDMD	P57764	ASPG	Homo sapiens	Q86U10	Y2H Array	32296183
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Validated Y2H	32296183
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Validated Y2H	25416956
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Y2H Array	32296183
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Y2H Prey Pooling	25416956
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ZBTB33	Homo sapiens	Q86T24	Validated Y2H	32296183
Intra	GSDMD	P57764	ZBTB33	Homo sapiens	Q86T24	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ZBTB33	Homo sapiens	Q86T24	Y2H Array	32296183
Cross	GSDMD	P57764	N	SARS-CoV-2	P0DTC9	Anti Bait CoIP	34296442
Cross	GSDMD	P57764	N	SARS-CoV-2	P0DTC9	Pull Down	34296442
Intra	GSDMD	P57764	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	PSMA1	Homo sapiens	P25786	Y2H Array	32296183
Intra	GSDMD	P57764	ZNF558	Homo sapiens	Q96NG5	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ZNF558	Homo sapiens	Q96NG5	Y2H Array	32296183
Intra	GSDMD	P57764	ZNF558	Homo sapiens	Q96NG5	Validated Y2H	32296183
Intra	GSDMD	P57764	CASP1	Homo sapiens	P29466	Pull Down	34296442
Intra	GSDMD	P57764	CASP1	Homo sapiens	P29466	Protease Assay	34296442
Intra	GSDMD	P57764	ZNF426	Homo sapiens	Q9BUY5	Validated Y2H	32296183
Intra	GSDMD	P57764	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	32296183
Intra	GSDMD	P57764	ZNF426	Homo sapiens	Q9BUY5	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cinca Syndrome

CINCA	Nomid
Cryopyrin-Associated Periodic Syndrome 3	Chronic Neurologic Cutaneous And Articular Syndrome
Multisystem Inflammatory Disease, Neonatal-Onset	Caps3
Chronic Infantile Neurological Cutaneous Articular Syndrome	Infantile-Onset Multisystem Inflammatory Disease
Iomid Syndrome	Neonatal-Onset Multisystem Inflammatory Disease
Nomid Syndrome	Prieur-Griscelli Syndrome
Neonatal Onset Multisystem Inflammatory Disease	Chronic Infantile Neurological, Cutaneous And Articular Syndrome
Iomid	Infantile Onset Multisystem Inflammatory Disease
Prieur Griscelli Syndrome	Chronic Infantile Neurological Cutaneous And Articular Syndrome
Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome	Chronic Infantile Neurologic Cutaneous And Articular Syndrome
Chronic Infantile Neurological, Cutaneous, And Articular Syndrome	Cryopyrin-Associated Periodic Syndromes

Familial Cold Autoinflammatory Syndrome

Familial Cold Urticaria	Fcas
Familial Polymorphous Cold Eruption	Fcu
Cold Hypersensitivity

Bacterial Sepsis

Salmonellosis

Salmonella Infections

Salmonella Infection

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-B0240	Disulfiram		99.78%	否
HY-B0240R	Disulfiram (Standard)		/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-13453	BAY 11-7082		99.98%	否
HY-127019	Nigericin		99.37%	否
HY-111674	LDC7559	Inhibitor	99.51%	否
HY-N0816	Polyphyllin VI		98.41%	否
HY-111675	Ac-FLTD-CMK	Inhibitor	99.53%	否
HY-152670	JC2-11	Inhibitor	98.02%	否
HY-RS05857	GSDMD Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-156374	D359-0396	Inhibitor	/	否
HY-161332	Antitumor agent-143		/	否
HY-161727	P2Y14R antagonist 1		/	否
HY-169018	CIB-1476	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	GSDMD	MGD	MGI:1916396
Macaca mulatta	GSDMD	VGNC	VGNC:73232
Rattus norvegicus	GSDMD	RGD	RGD:1307261
Canis familiaris	GSDMD	VGNC	VGNC:41526
Felis catus	GSDMD	VGNC	VGNC:62726
Bos taurus	GSDMD	VGNC	VGNC:29675

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