2. Apoptosis Immunology/Inflammation Metabolic Enzyme/Protease NF-κB
  3. Ferroptosis Pyroptosis Apoptosis Reactive Oxygen Species
  4. Antitumor agent-143

Antitumor agent-143 (compound 2c) 是一种抗肿瘤剂，可阻断 A549 细胞 S 期的细胞增殖并诱导早期凋亡 (apoptosis)。Antitumor agent-143 通过铁死亡 (ferroptosis) 诱导细胞死亡，通过 ROS 介导的线粒体功能障碍途径诱导细胞凋亡，以及 GSDMD 介导的细胞焦亡 (pyroptosis)。

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Antitumor agent-143 Chemical Structure

Antitumor agent-143 Chemical Structure

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Antitumor agent-143 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-143 (compound 2c) is an antitumor agent that blocks cell proliferation of A549 cells during the S phase and induces an early apoptosis. Antitumor agent-143 induces cell death via ferroptosis, apoptosis by a ROS-mediated mitochondrial dysfunction pathway and GSDMD-mediated pyroptosis[1].

体外研究
(In Vitro)

Antitumor agent-143（compound 2c；48h）抑制 A549、B16、HCT116 和 HepG2 细胞的生长，IC50 值分别为 2.2 μM、2.5 μM、2.5 μM 和 1 μM[1] .
Antitumor agent-143 (compound 2c) 可阻断 A549 细胞 S 期的细胞增殖并诱导早期细胞凋亡[1]。
Antitumor agent-143 (compound 2c) 会导致 ROS 和 Ca2+ 量升高。 这导致线粒体膜电位降低、线粒体通透性转换孔开放以及细胞色素 c[1] 增加。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-143 相关抗体:
体内研究
(In Vivo)

Antitumor agent-143 (compound 2c) 减少了小鼠的肿瘤体积[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (3-4 weeks) injected with A549 cells[1]
Dosage: 3.2 or 5.0 mg/kg
Administration: Intraperitoneal injection; daily; for 7 days
Result: Exhibited a remarkable inhibitory rate of 58.58% in restraining tumor growth.
分子量

1127.88

Formula

C47H29Cl2F6IrN9P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-143 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-143Antitumor agent143Antitumor agent 143FerroptosisPyroptosisApoptosisReactive Oxygen Speciesferroptosispyroptosisapoptosismitochondrial dysfunctionantitumor agentInhibitorinhibitorinhibit

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