2. Gene
  3. ZNF558 - zinc finger protein 558 Gene

ZNF558 - zinc finger protein 558 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：锌指蛋白 558

种属: Homo sapiens

基因 ID: 148156 | 基因类型: protein coding

关于 ZNF558

This gene has 7 transcripts (splice variants), 157 orthologues and 62 paralogues. Ubiquitous expression in endometrium (RPKM 6.2), thyroid (RPKM 6.0) and 25 other tissues.

功能概要

预测可启用 DNA 结合转录抑制活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 转录调节区序列特异性 DNA 结合活性。预计参与 RNA 聚合酶 II 对转录的负调控。预测位于核内。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF558 基因产物(2)

mRNA Protein Name
NM_001304350.2 NP_001291279.1 zinc finger protein 558 isoform 2
NM_144693.3 NP_653294.1 zinc finger protein 558 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZNF558 蛋白结构

KRAB

KRAB: KRAB box (43 - 83)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (166 - 191)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (195 - 218)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (222 - 246)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (250 - 275)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (279 - 302)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (307 - 331)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (334 - 359)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (363 - 387)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
蛋白主名 其他名称

zinc finger protein 558

ZNF558 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZNF558 Q96NG5 MAD2L2 Homo sapiens Q9UI95
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Endometrial Mixed Adenocarcinoma
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16153 ZNF558 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZNF558 MGD MGI:1921681
Rattus norvegicus ZNF558 RGD RGD:9264599
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