2. Gene
  3. APIP - APAF1 interacting protein Gene

APIP - APAF1 interacting protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：APAF1 相互作用蛋白

种属: Homo sapiens

同用名: APIP2; CGI29; hAPIP; CGI-29; MMRP19

基因 ID: 51074 | 基因类型: protein coding

关于 APIP

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,882,295-34,916,379 (from NCBI)

This gene has 3 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in fat (RPKM 15.7), adrenal (RPKM 13.7) and 25 other tissues.

功能概要

APIP 是一种 APAF1 (MIM 602233) 相互作用蛋白，可作为缺血/缺氧损伤的负调节因子 (Cho 等人，2004 [PubMed 15262985]) 。[OMIM 提供，2008 年 12 月]

APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]

APIP 基因产物(1)

mRNA Protein Name
NM_015957.4 NP_057041.2 methylthioribulose-1-phosphate dehydratase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables methylthioribulose 1-phosphate dehydratase activity IDA
IDA: 通过直接分析推断
24367089 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
24367089 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-methionine salvage from methylthioadenosine IMP
IMP: 通过突变表型推断
22837397 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
22837397 GOA
involved in protein homotetramerization IDA
IDA: 通过直接分析推断
24367089 GOA
involved in pyroptotic inflammatory response IMP
IMP: 通过突变表型推断
24367089 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23285211 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

APIP 蛋白结构

Aldolase_II

Aldolase_II: Class II Aldolase and Adducin N-terminal domain (28 - 221)

  • 0
  • 100
  • 200
  • 242 a.a.
蛋白主名 其他名称

methylthioribulose-1-phosphate dehydratase

MTRu-1-P dehydratase

APIP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra APIP Q96GX9 PDZD4 Homo sapiens Q17RL8
Y2H Array
31515488
Intra APIP Q96GX9 PDZD4 Homo sapiens Q17RL8
Validated Y2H
25416956
Intra APIP Q96GX9 SKP1 Homo sapiens P63208
Y2H Prey Pooling
25416956
Intra APIP Q96GX9 SKP1 Homo sapiens P63208
Y2H Array
25416956
Intra APIP Q96GX9 IMPDH2 Homo sapiens P12268
Y2H Array
25416956
Intra APIP Q96GX9 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra APIP Q96GX9 APIP Homo sapiens Q96GX9
Y2H Pooling
16189514
Intra APIP Q96GX9 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
Intra APIP Q96GX9 APIP Homo sapiens Q96GX9
Pull Down
16189514
Intra APIP Q96GX9 APIP Homo sapiens Q96GX9
Y2H Array
31515488
Intra APIP Q96GX9 APIP Homo sapiens Q96GX9
Y2H Prey Pooling
25416956
Intra APIP Q96GX9 APIP Homo sapiens Q96GX9
Validated Y2H
25416956
Intra APIP Q96GX9 APIP Homo sapiens Q96GX9
Y2H Prey Pooling
32296183
Intra APIP Q96GX9 APIP Homo sapiens Q96GX9
Y2H Array
19060904
Intra APIP Q96GX9 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra APIP Q96GX9 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra APIP Q96GX9 NUDT18 Homo sapiens Q6ZVK8
Y2H Pooling
16189514
Intra APIP Q96GX9 APIP Homo sapiens Q96GX9
Validated Y2H
32296183
Intra APIP Q96GX9 APIP Homo sapiens Q96GX9
Y2H Array
25416956
Intra APIP Q96GX9 APIP Homo sapiens Q96GX9
Y2H Pooling
19060904
Intra APIP Q96GX9 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
Intra APIP Q96GX9 APIP Homo sapiens Q96GX9
Y2H Array
32296183
Intra APIP Q96GX9 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
25416956
Intra APIP Q96GX9 PSMA1 Homo sapiens P25786
Validated Y2H
25416956
Intra APIP Q96GX9 SMN1 Homo sapiens Q16637
Validated Y2H
32814053
Intra APIP Q96GX9 SMN1 Homo sapiens Q16637
Y2H Array
32814053
Intra APIP Q96GX9 SMN1 Homo sapiens Q16637
Y2H Pooling
32814053
Intra APIP Q96GX9 TNPO2 Homo sapiens O14787
Y2H Prey Pooling
25416956
Intra APIP Q96GX9 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra APIP Q96GX9 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
25416956
Intra APIP Q96GX9 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
25416956
Intra APIP Q96GX9 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Prey Pooling
25416956
Intra APIP Q96GX9 NTAQ1 Homo sapiens Q96HA8
Y2H Array
31515488
Intra APIP Q96GX9 CFAP206 Homo sapiens Q8IYR0
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Endocervicitis
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00820 APIP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta APIP VGNC VGNC:99543
Mus musculus APIP MGD MGI:1926788
Felis catus APIP VGNC VGNC:59850
Bos taurus APIP VGNC VGNC:26016
Canis familiaris APIP VGNC VGNC:37986
Rattus norvegicus APIP RGD RGD:1564562
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