UBXN11 - UBX domain protein 11 Gene

中文名称：UBX 结构域蛋白 11

种属: Homo sapiens

同用名: SOC; SOCI; COA-1; UBXD5; PP2243

关于 UBXN11

功能概要

该基因编码的蛋白质具有不同的 C 端 UBX 结构域。大鼠中的同源蛋白通过其 C 末端区域与细胞外周 Rho GTP 酶的 Rnd 亚家族成员相互作用。它还通过 G-alpha 亚基与几种异源三聚体 G 蛋白相互作用并促进 Rho GTPase 激活。建议通过上游信号通路在促进和抑制 Rho 活性方面发挥双向作用。该基因的 3' 编码序列包含一个 24 nt 串联重复的多态性区域。已经报道了几个包含 1.5 到 5 个重复单元的转录本。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]