RGS19 - regulator of G protein signaling 19 Gene

中文名称：G 蛋白信号调节因子 19

种属: Homo sapiens

同用名: GAIP; RGSGAIP

基因 ID: 10287 | 基因类型: protein coding

关于 RGS19

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:64,073,181-64,079,964 (from NCBI)

This gene has 4 transcripts (splice variants), 184 orthologues and 23 paralogues. Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 8.6) and 21 other tissues.

功能概要

蛋白介导许多细胞过程。该基因编码的蛋白质属于 RGS (G 蛋白信号调节因子) 家族，与 G 蛋白 GAI3 特异性相互作用。这种蛋白质是一种鸟苷三磷酸酶激活蛋白，其功能是下调 Galpha i/Galpha q 连锁信号。已为该基因发现了编码相同蛋白质同种型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

RGS19 基因产物(7)

mRNA	Protein	Name
XM_005260182.4	XP_005260239.1	regulator of G-protein signaling 19 isoform X3
NM_001039467.2	NP_001034556.1	regulator of G-protein signaling 19
NM_005873.3	NP_005864.1	regulator of G-protein signaling 19
XM_011528484.3	XP_011526786.1	regulator of G-protein signaling 19 isoform X1
XM_011528485.3	XP_011526787.1	regulator of G-protein signaling 19 isoform X2
XM_047439824.1	XP_047295780.1	regulator of G-protein signaling 19 isoform X2
XM_005260183.3	XP_005260240.1	regulator of G-protein signaling 19 isoform X3

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	8524874	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RGS19 蛋白结构

RGS

0
100
200
217 a.a.

蛋白主名

其他名称

regulator of G-protein signaling 19

G alpha interacting protein	G protein signalling regulator 19
guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein	regulator of G-protein signalling 19

RGS19 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RGS19	P49795	LCE4A	Homo sapiens	Q5TA78	Validated Y2H	32296183
种属内	RGS19	P49795	VASN	Homo sapiens	Q6EMK4	Validated Y2H	32296183
种属内	RGS19	P49795	KRTAP5-6	Homo sapiens	Q6L8G9	Validated Y2H	32296183
种属内	RGS19	P49795	NUFIP2	Homo sapiens	Q7Z417	Validated Y2H	32296183
种属内	RGS19	P49795	POU4F2	Homo sapiens	Q12837	Validated Y2H	32296183
种属内	RGS19	P49795	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
种属间	RGS19	P49795	Gnai3	Rattus norvegicus	P08753	Y2H	8524874
种属间	RGS19	P49795	Gnai3	Rattus norvegicus	P08753	Pull Down	8524874

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Deafness, Autosomal Recessive 15

DFNB15	Dfnb72
Dfnb95	Deafness, Autosomal Recessive 72
Autosomal Recessive Nonsyndromic Deafness 15	Deafness, Autosomal Recessive 95
Autosomal Recessive Deafness 15	Autosomal Recessive Deafness 72
Autosomal Recessive Deafness 95	Deafness, Autosomal Recessive, 15
Deafness Autosomal Recessive 72	Deafness Autosomal Recessive 95
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 15	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 15
Deafness, Autosomal Recessive, Type 15

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-13509	CCG-50014	Inhibitor	99.42%	否
HY-U00431	CCG 203769	Inhibitor	99.76%	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	RGS19	VGNC	VGNC:45528
Felis catus	RGS19	VGNC	VGNC:64594
Rattus norvegicus	RGS19	RGD	RGD:629471
Mus musculus	RGS19	MGD	MGI:1915153
Macaca mulatta	RGS19	VGNC	VGNC:108027
Bos taurus	RGS19	VGNC	VGNC:33918

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