HOXC11 - homeobox C11 Gene

中文名称：同源框 C11

种属: Homo sapiens

同用名: HOX3H

关于 HOXC11

功能概要

该基因属于同源盒基因家族。同源框基因编码一个高度保守的转录因子家族，在所有多细胞生物的形态发生中起着重要作用。哺乳动物拥有 4 个相似的同源盒基因簇 HOXA、HOXB、HOXC 和 HOXD，它们分别位于不同的染色体上，由 9～11 个串联排列的基因组成。该基因是位于 12 号染色体簇中的几个同源框 HOXC 基因之一。该基因的产物与乳糖酶-根皮苷水解酶的启动子元件结合。它还可能在早期肠道发育中发挥作用。已经描述了编码较短同种型的可变剪接变体，但尚未确定其全长性质。[RefSeq 提供，2008 年 7 月]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]