SPDEF - SAM pointed domain containing ETS transcription factor Gene

中文名称：含 ETS 转录因子的 SAM 指向域

种属: Homo sapiens

同用名: PDEF; bA375E1.3

基因 ID: 25803 | 基因类型: protein coding

关于 SPDEF

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,537,802-34,556,329 (from NCBI)

This gene has 2 transcripts (splice variants), 245 orthologues and 28 paralogues. Biased expression in prostate (RPKM 50.1), salivary gland (RPKM 10.8) and 5 other tissues.

功能概要

该基因编码的蛋白质属于 ETS 转录因子家族。它在前列腺上皮细胞中高度表达，并作为前列腺特异性抗原 (PSA) 启动子的雄激素非依赖性反式激活因子发挥作用。与相应的正常组织相比，这种蛋白质在脑、乳腺、肺和卵巢肿瘤中的表达也更高，并且它显示出比其他癌症相关分子更好的肿瘤相关性，使其成为发展特定癌症的更合适的靶点疗法。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 11 月]

The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific Cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SPDEF 基因产物(2)

mRNA	Protein	Name
NM_001252294.2	NP_001239223.1	SAM pointed domain-containing Ets transcription factor isoform 2
NM_012391.3	NP_036523.1	SAM pointed domain-containing Ets transcription factor isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	21656828	GOA
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	21656828	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPDEF 蛋白结构

SAM_PNT

Ets

0
100
200
300
335 a.a.

蛋白主名

其他名称

SAM pointed domain-containing Ets transcription factor

prostate epithelium-specific Ets transcription factor

SPDEF 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SPDEF	O95238	CEP57	Homo sapiens	Q86XR8-3	Validated Y2H	32296183
Intra	SPDEF	O95238	SNX20	Homo sapiens	Q7Z614-3	Validated Y2H	32296183
Intra	SPDEF	O95238	PSMA1	Homo sapiens	P25786	Validated Y2H	32296183
Intra	SPDEF	O95238	COX5A	Homo sapiens	P20674	Validated Y2H	32296183
Intra	SPDEF	O95238	FAM161B	Homo sapiens	Q96MY7	Validated Y2H	32296183
Intra	SPDEF	O95238	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	SPDEF	O95238	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Allergic Cutaneous Vasculitis

Allergic Cutaneous Angiitis	Autoimmune Hypersensitivity Angiitis
Vasculitis, Leukocytoclastic, Cutaneous

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Ascending Colon Cancer

Malignant Tumor Of Ascending Colon	Ca Ascending Colon
Malignant Neoplasm Of Right Colon	Malignant Neoplasm Of Ascending Colon

Lung Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Lung

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-B0603	Fluticasone	Agonist	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13652	SPDEF Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SPDEF	VGNC	VGNC:65628
Macaca mulatta	SPDEF	VGNC	VGNC:104430
Canis familiaris	SPDEF	VGNC	VGNC:46726
Rattus norvegicus	SPDEF	RGD	RGD:1594842
Mus musculus	SPDEF	MGD	MGI:1353422
Bos taurus	SPDEF	VGNC	VGNC:35198

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SPDEF - SAM pointed domain containing ETS transcription factor Gene

关于 SPDEF

功能概要

SPDEF 基因产物(2)

SPDEF 蛋白结构

SPDEF 蛋白互作信息

关联疾病

直系同源

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SPDEF - SAM pointed domain containing ETS transcription factor Gene

关于 SPDEF

功能概要

SPDEF 基因产物(2)

SPDEF 蛋白结构

SPDEF 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

L

N

Q

S

T

X

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