1. Gene
  2. IPO13 - importin 13 Gene

IPO13 - importin 13 Gene

中文名称:导入 13

种属: Homo sapiens

同用名: LGL2; IMP13; KAP13; RANBP13

基因 ID: 9670 | 基因类型: protein coding

关于 IPO13

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:43,946,950-43,968,022 (from NCBI)

This gene has 7 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in testis (RPKM 29.4), brain (RPKM 19.8) and 24 other tissues.

功能概要

该基因编码核转运蛋白 importin-beta 家族的成员。编码的蛋白质介导特定货物蛋白从细胞质到细胞核的输入,并依赖于 Ras 相关核蛋白-GTPase 系统。编码的蛋白质还参与真核翻译起始因子 1A 的核输出。[RefSeq 提供,2009 年 3 月]

This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]

IPO13 基因产物(1)

mRNA Protein Name
NM_014652.4 NP_055467.3 importin-13

IPO13 蛋白结构

IBN_N

IBN_N: Importin-beta N-terminal domain (45 - 109)

Xpo1

Xpo1: Exportin 1-like protein (117 - 262)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 963 a.a.
蛋白主名 其他名称

importin-13

Ran binding protein 13

IPO13 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra IPO13 O94829 PBX4 Homo sapiens Q9BYU1
Y2H Array
25416956
Intra IPO13 O94829 PBX4 Homo sapiens Q9BYU1
Y2H Array
29892012
Intra IPO13 O94829 PBX4 Homo sapiens Q9BYU1
Y2H Array
31515488
Intra IPO13 O94829 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
Intra IPO13 O94829 PBX4 Homo sapiens Q9BYU1
Validated Y2H
25416956
Intra IPO13 O94829 EIF1AX Homo sapiens P47813
Pull Down
23435562
Intra IPO13 O94829 EIF1AX Homo sapiens P47813
GMS
23435562
Intra IPO13 O94829 EIF1AX Homo sapiens P47813
Competition Binding
21139563
Intra IPO13 O94829 PAX3 Homo sapiens P23760-8
Validated Y2H
32296183
Intra IPO13 O94829 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
32296183
Intra IPO13 O94829 RAN Homo sapiens P62826
Pull Down
21139563
Intra IPO13 O94829 RAN Homo sapiens P62826
Competition Binding
21139563
Intra IPO13 O94829 RAN Homo sapiens P62826
Pull Down
23435562
Intra IPO13 O94829 MAGOH Homo sapiens P61326
TSA
23435562
Intra IPO13 O94829 MAGOH Homo sapiens P61326
Pull Down
23435562
Intra IPO13 O94829 MAGOH Homo sapiens P61326
Pull Down
21139563
Intra IPO13 O94829 PSMA1 Homo sapiens P25786
Validated Y2H
32296183
Intra IPO13 O94829 PITX1 Homo sapiens P78337
Validated Y2H
32296183
Intra IPO13 O94829 UBE2I Homo sapiens P63279
TSA
23435562
Intra IPO13 O94829 UBE2I Homo sapiens P63279
Pull Down
23435562
Intra IPO13 O94829 UBE2I Homo sapiens P63279
Pull Down
21139563
Intra IPO13 O94829 UBE2I Homo sapiens P63279
X-Ray Diffraction
21139563
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Partington Syndrome

X-Linked Reticulate Pigmentary Disorder

PRTS

Partington X-Linked Mental Retardation Syndrome

Mrxs1

Mrx36

Intellectual Developmental Disorder, X-Linked, Syndromic 1

Partington Disease

Pdr

Partington-Mulley Syndrome

Russell-Silver Syndrome, X-Linked

Mental Retardation, X-Linked, Syndromic 1

Mental Retardation, X-Linked, With Dystonic Movements, Ataxia, And Seizures

Mental Retardation, X-Linked 36

X-Linked Reticulate Pigmentary Disorder With Systemic Manifestations

X-Linked Russell-Silver Syndrome

Intelectual Disability-Dystonic Movements-Ataxia-Seizures Syndrome

Intellectual Disability, X-Linked, Syndromic 1

Intellectual Disability, X-Linked, With Dystonic Movements, Ataxia, And Seizures

Partington X-Linked Intellectual Disability Syndrome

X-Linked Intellectual Deficit-Dystonia-Dysarthria

X-Linked Mental Retardation With Dystonic Movements, Ataxia, And Seizures

Familial Cutaneous Amyloidosis

X-Linked Cutaneous Amyloidosis

Xlpdr

X-Linked Intellectual Disability-Dystonia-Dysarthria Syndrome

Pigmentary Disorder, Reticulate, With Systemic Manifestations

Corpus Callosum, Agenesis Of, With Abnormal Genitalia

Proud Syndrome

Corpus Callosum Agenesis-Abnormal Genitalia Syndrome

Acc With Abnormal Genitalia

Proud-Levine-Carpenter Syndrome

Microcephaly-Corpus Callosum Agenesis-Abnormal Genitalia Syndrome

Corpus Callosum Agenesis With Abnormal Genitalia

New X-Linked Syndrome With Seizures, Acquired Micrencephaly, And Agenesis Of The Corpus Callosum

Proud Levine Carpenter Syndrome

Acc-Abnormal Genitalia Syndrome

Agenesis Of The Corpus Callosum, With Abnormal Genitalia

ACCAG

Micrencephaly-Corpus Callosum Agenesis-Abnormal Genitalia

Congenital Neurologic Anomalies

Myiasis

Infestation By Fly Larvae

Infestation By Maggots

Maggot Infestation

Infestation By Larvae Of Flies

Infestation By Dermatobia

Infestation By Estrus Ovis

Infestation By Oestrus Ovis

Oestriasis

Oestrosis

Lissencephaly, X-Linked, 2

X-Linked Lissencephaly With Abnormal Genitalia

Hydranencephaly With Abnormal Genitalia

Xlag

Xlisg

X-Linked Lissencephaly With Ambiguous Genitalia

LISX2

Lissencephaly, X-Linked 2

X-Linked Lissencephaly 2

X-Linked Lissencephaly-Corpus Callosum Agenesis-Genital Anomalies Syndrome

Xlag Syndrome

Lissencephaly, X-Linked, With Ambiguous Genitalia

Xlis2

X-Linked Lissencephaly - Agenesis Of The Corpus Callosum - Genital Anomalies

X-Linked Lissencephaly-Agenesis Of The Corpus Callosum-Genital Anomalies Syndrome

Xlag Syndrome

Lissencephaly X-Linked With Ambiguous Genitalia

Lissencephaly, X-Linked, Type 2

Chromosome Xq26.3 Duplication Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus IPO13 MGD MGI:2385205
Rattus norvegicus IPO13 RGD RGD:620071
Canis familiaris IPO13 VGNC VGNC:42064
Bos taurus IPO13 VGNC VGNC:30241
Macaca mulatta IPO13 VGNC VGNC:73609
Felis catus IPO13 VGNC VGNC:62954