2. Gene
  3. DCTD - dCMP deaminase Gene

DCTD - dCMP deaminase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：dCMP 脱氨酶

种属: Homo sapiens

基因 ID: 1635 | 基因类型: protein coding

关于 DCTD

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:182,890,091-182,917,611 (from NCBI)

This gene has 17 transcripts (splice variants), 245 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 37.0), adrenal (RPKM 19.8) and 25 other tissues.

功能概要

由该基因编码的蛋白质催化 dCMP 脱氨为 dUMP，dUMP 是胸苷酸合酶的核苷酸底物。编码的蛋白质被 dCTP 变构激活并被 dTTP 抑制，并且被发现为同源六聚体。这种蛋白质使用锌作为其活性的辅因子。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for Thymidylate Synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DCTD 基因产物(9)

mRNA Protein Name
NM_001012732.2 NP_001012750.1 deoxycytidylate deaminase isoform a
NM_001351743.2 NP_001338672.1 deoxycytidylate deaminase isoform b
NM_001351744.2 NP_001338673.1 deoxycytidylate deaminase isoform b
NM_001351745.2 NP_001338674.1 deoxycytidylate deaminase isoform b
NM_001351747.2 NP_001338676.1 deoxycytidylate deaminase isoform b
NM_001351748.2 NP_001338677.1 deoxycytidylate deaminase isoform b
NM_001351750.2 NP_001338679.1 deoxycytidylate deaminase isoform b
NM_001351753.2 NP_001338682.1 deoxycytidylate deaminase isoform b
NM_001921.3 NP_001912.2 deoxycytidylate deaminase isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity IDA
IDA: 通过直接分析推断
33833118 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in nucleoside salvage IMP
IMP: 通过突变表型推断
33833118 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DCTD 蛋白结构

dCMP_cyt_deam_1

dCMP_cyt_deam_1: Cytidine and deoxycytidylate deaminase zinc-binding region (14 - 128)

  • 0
  • 100
  • 178 a.a.
蛋白主名 其他名称

deoxycytidylate deaminase

DCTD 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DCTD P32321 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra DCTD P32321 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra DCTD P32321 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra DCTD P32321 MALSU1 Homo sapiens Q96EH3
Y2H Prey Pooling
25416956
Intra DCTD P32321 MALSU1 Homo sapiens Q96EH3
Validated Y2H
25416956
Intra DCTD P32321 MALSU1 Homo sapiens Q96EH3
Validated Y2H
32296183
Intra DCTD P32321 TXN2 Homo sapiens Q99757
Y2H Prey Pooling
25416956
Intra DCTD P32321 TXN2 Homo sapiens Q99757
Validated Y2H
25416956
Intra DCTD P32321 TXN2 Homo sapiens Q99757
Y2H Array
25416956
Intra DCTD P32321 FGF12 Homo sapiens P61328
Y2H Array
25416956
Intra DCTD P32321 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra DCTD P32321 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
29892012
Intra DCTD P32321 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
Intra DCTD P32321 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
25416956
Intra DCTD P32321 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra DCTD P32321 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
25416956
Intra DCTD P32321 DCTD Homo sapiens P32321
Y2H
21988832
Intra DCTD P32321 DCTD Homo sapiens P32321
Y2H Prey Pooling
32296183
Intra DCTD P32321 DCTD Homo sapiens P32321
Validated Y2H
32296183
Intra DCTD P32321 DCTD Homo sapiens P32321
Y2H Array
32296183
Intra DCTD P32321 DCTD Homo sapiens P32321
Y2H Pooling
16189514
Intra DCTD P32321 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Granulomatosis With Polyangiitis

GPA

Wegener Granulomatosis

Wegener Granulomatosis, Formerly

Midline Granulomatosis

Wg, Formerly

Necrotizing Respiratory Granulomatosis

Wg

Wegeners Granulomatosis

Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03592 DCTD Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta DCTD VGNC VGNC:71750
Canis familiaris DCTD VGNC VGNC:39815
Bos taurus DCTD VGNC VGNC:27927
Mus musculus DCTD MGD MGI:2444529
Felis catus DCTD VGNC VGNC:107325
Rattus norvegicus DCTD RGD RGD:1359671
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