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  4. Cedazuridine hydrochloride

Cedazuridine hydrochloride  (Synonyms: E7727 hydrochloride)

目录号: HY-109081A
产品使用指南

摩尔计算器

Cedazuridine (E7727) (Compound 7a) hydrochloride 是一种具有口服活性的胞苷脱氨酶 (CDA) 抑制剂，其 IC50 值为 0.4 μM。Cedazuridine hydrochloride 可用于癌症的研究。

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Cedazuridine hydrochloride Chemical Structure

Cedazuridine hydrochloride Chemical Structure

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Cedazuridine hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Cedazuridine hydrochloride:

Cedazuridine hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cedazuridine (E7727) (Compound 7a) hydrochloride is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine hydrochloride can be used for cancer research[1].

IC50 & Target

IC50: 0.4 μM (CDA)[1]
体外研究
(In Vitro)

Cedazuridine (Compound 7a) exhibits superior acid stability[1].
Cedazuridine (0-10 μM; 72 h) does not enhance effects of AZA (5-Azacytidine, HY-10586) in growth inhibition of AML cell lines[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cedazuridine hydrochloride 相关抗体:
体内研究
(In Vivo)

Cedazuridine (3 mg/kg; p.o.; daily for 7 days) in combination with 2.5 mg/kg AZA shows tumor regression in mice MOLM-13 CDX and PDX models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NSGS mice, 6–8 weeks old, human cell line-derived (CDX) and primary patient-derived xenograft (PDX) models[2]
Dosage: 3 mg/kg
Administration: Oral administration, in combination with 2.5 mg/kg AZA, daily for 7 days
Result: Led to reduction of leukemic expansion in combination with AZA in a cell line-derived xenograft transplantation, and exhibited preliminary safety and efcacy in a primary AML PDX model.
Animal Model: NSGS male mice[2]
Dosage: 1, 3, 10 and 30 mg/kg
Administration: Oral, in combination with 2.5 mg/kg AZA (Pharmacokinetic Studies)
Result: Dose-dependently increased the AUC of oral AZA and in comparison to dosing of standard i.p. AZA.
Clinical Trial
分子量

304.68

Formula

C9H15ClF2N2O5
中文名称

盐酸西达尿苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cedazuridine hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CedazuridineE7727盐酸西达尿苷E 7727E-7727Otherscytidine deaminaseCDAcancerazacitidineInhibitorinhibitorinhibit

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目录号：
HY-109081A
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