STAM2 - signal transducing adaptor molecule 2 Gene

中文名称：信号转导衔接分子 2

种属: Homo sapiens

同用名: Hbp; STAM2A; STAM2B

关于 STAM2

功能概要

该基因编码的蛋白质与 STAM 密切相关，STAM 是一种参与细胞因子受体下游信号传导的衔接蛋白，两者均包含 SH3 结构域和基于免疫受体酪氨酸的激活基序 (ITAM) 。与 STAM 类似，该蛋白作用于 JAK 激酶的下游，并响应于细胞因子刺激而被磷酸化。因此，这种蛋白质和 STAM 被认为在细胞因子刺激后对 JAK 激酶下游的信号通路表现出补偿作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of Cytokine Receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]