1. Gene
  2. UBXN2A - UBX domain protein 2A Gene

UBXN2A - UBX domain protein 2A Gene

中文名称:UBX 结构域蛋白 2A

种属: Homo sapiens

同用名: UBXD4

基因 ID: 165324 | 基因类型: protein coding

关于 UBXN2A

This gene has 4 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 3.2), esophagus (RPKM 2.9) and 25 other tissues.

功能概要

预测启用泛素结合活性。预计参与多个过程,包括自噬体组装;核膜重组;和蛋白酶体介导的泛素依赖性蛋白质分解代谢过程。预计在对白血病抑制因子的细胞反应上游或细胞反应中发挥作用;基因表达的调节;蛋白质代谢过程的调控。预测位于顺式高尔基体网络和内质网。预计在胞质溶胶和细胞核中有活性。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including autophagosome assembly; nuclear membrane reassembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; regulation of gene expression; and regulation of protein metabolic process. Predicted to be located in cis-Golgi network and endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

UBXN2A 基因产物(1)

mRNA Protein Name
NM_181713.4 NP_859064.2 UBX domain-containing protein 2A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21900206 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of ERAD pathway IMP
IMP: 通过突变表型推断
26265139 GOA
involved in negative regulation of proteolysis IMP
IMP: 通过突变表型推断
26634371 GOA
involved in positive regulation of protein catabolic process IMP
IMP: 通过突变表型推断
37037900 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
24625977 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24625977 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

UBXN2A 蛋白结构

SEP

SEP: SEP domain (65 - 138)

UBX

UBX: UBX domain (172 - 246)

  • 0
  • 100
  • 200
  • 259 a.a.
蛋白主名 其他名称

UBX domain-containing protein 2A

UBX domain containing 4

UBXN2A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra UBXN2A P68543 UBXN6 Homo sapiens Q9BZV1
Validated Y2H
32296183
Intra UBXN2A P68543 VCP Homo sapiens P55072
Y2H Prey Pooling
32296183
Intra UBXN2A P68543 VCP Homo sapiens P55072
Validated Y2H
32814053
Intra UBXN2A P68543 VCP Homo sapiens P55072
Y2H Pooling
32814053
Intra UBXN2A P68543 VCP Homo sapiens P55072
BRET
29997244
Intra UBXN2A P68543 VCP Homo sapiens P55072
Y2H Array
32814053
Intra UBXN2A P68543 VCP Homo sapiens P55072
Anti Tag CoIP
33961781
Intra UBXN2A P68543 VCP Homo sapiens P55072
Y2H Array
32296183
Intra UBXN2A P68543 VCP Homo sapiens P55072
Anti Tag CoIP
28514442
Intra UBXN2A P68543 VCP Homo sapiens P55072
Lumier
29997244
Intra UBXN2A P68543 DYDC2 Homo sapiens Q96IM9
Validated Y2H
32296183
Intra UBXN2A P68543 DYDC2 Homo sapiens Q96IM9
Y2H Array
32296183
Intra UBXN2A P68543 DYDC2 Homo sapiens Q96IM9
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta UBXN2A VGNC VGNC:79657
Canis familiaris UBXN2A VGNC VGNC:48098
Mus musculus UBXN2A MGD MGI:2442310
Felis catus UBXN2A VGNC VGNC:66792
Bos taurus UBXN2A VGNC VGNC:36625
Rattus norvegicus UBXN2A RGD RGD:1589027