2. Gene
  3. UBXN1 - UBX domain protein 1 Gene

UBXN1 - UBX domain protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：UBX 结构域蛋白 1

种属: Homo sapiens

同用名: 2B28; SAKS1; UBXD10

基因 ID: 51035 | 基因类型: protein coding

关于 UBXN1

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,676,500-62,679,073 (from NCBI)

This gene has 18 transcripts (splice variants), 197 orthologues and 5 paralogues. Ubiquitous expression in ovary (RPKM 47.6), fat (RPKM 40.5) and 25 other tissues.

功能概要

启用多种功能，包括酶结合活性；多聚泛素修饰依赖性蛋白结合活性；和蛋白酶体调节颗粒结合活性。参与细胞蛋白质代谢过程的负调控。位于胞质溶胶中；内质网；和核质。 VCP-NPL4-UFD1 AAA ATPase 复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including Enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and Proteasome regulatory particle binding activity. Involved in negative regulation of cellular protein metabolic process. Located in cytosol; endoplasmic reticulum; and nucleoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]

UBXN1 基因产物(3)

mRNA Protein Name
NM_001286077.2 NP_001273006.1 UBX domain-containing protein 1 isoform 2
NM_001286078.2 NP_001273007.1 UBX domain-containing protein 1 isoform 3
NM_015853.5 NP_056937.2 UBX domain-containing protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase binding IPI
IPI: 通过物理相互作用推断
15362974 GOA
enables K48-linked polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
21135095 GOA
enables K6-linked polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
20351172 GOA
enables polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
15362974 GOA
enables proteasome regulatory particle binding IDA
IDA: 通过直接分析推断
15362974 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18775313 GOA
enables ubiquitin binding IDA
IDA: 通过直接分析推断
18775313 GOA
enables ubiquitin protein ligase binding IDA
IDA: 通过直接分析推断
18775313 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of ERAD pathway IMP
IMP: 通过突变表型推断
21135095 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
20351172 GOA
involved in negative regulation of protein K48-linked deubiquitination IDA
IDA: 通过直接分析推断
21135095 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
20351172 GOA
involved in negative regulation of ubiquitin-specific protease activity IDA
IDA: 通过直接分析推断
21135095 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of VCP-NPL4-UFD1 AAA ATPase complex IDA
IDA: 通过直接分析推断
18775313 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
10942595 GOA
located in cytosol IDA
IDA: 通过直接分析推断
21135095 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
21135095 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBXN1 蛋白结构

UBA

UBA: UBA/TS-N domain (6 - 39)

UBX

UBX: UBX domain (209 - 292)

  • 0
  • 100
  • 200
  • 297 a.a.
蛋白主名 其他名称

UBX domain-containing protein 1

SAPK substrate protein 1

UBXN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra UBXN1 Q04323 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra UBXN1 Q04323 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra UBXN1 Q04323 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra UBXN1 Q04323 UBE2I Homo sapiens Q7KZS0
Validated Y2H
25416956
Intra UBXN1 Q04323 UBE2I Homo sapiens Q7KZS0
Y2H Array
25416956
Intra UBXN1 Q04323 PLAA Homo sapiens Q9Y263
Y2H Array
25416956
Intra UBXN1 Q04323 PLAA Homo sapiens Q9Y263
Anti Tag CoIP
18775313
Intra UBXN1 Q04323 VCP Homo sapiens P55072
Anti Tag CoIP
18775313
Intra UBXN1 Q04323 VCP Homo sapiens P55072
Y2H Array
25416956
Intra UBXN1 Q04323 VCP Homo sapiens P55072
Validated Y2H
25416956
Intra UBXN1 Q04323 TRIM39 Homo sapiens Q9HCM9
Y2H Array
25416956
Intra UBXN1 Q04323 TRIM39 Homo sapiens Q9HCM9
Validated Y2H
25416956
Intra UBXN1 Q04323 q8wu02_human Homo sapiens Q8WU02
Y2H Prey Pooling
25416956
Intra UBXN1 Q04323 q8wu02_human Homo sapiens Q8WU02
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia

Pagetoid Amyotrophic Lateral Sclerosis

Pagetoid Neuroskeletal Syndrome

Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia

Multisystem Proteinopathy

Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone

Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement

Lower Motor Neuron Degeneration With Paget-Like Bone Disease

Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone

Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15394 UBXN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus UBXN1 MGD MGI:1289301
Bos taurus UBXN1 VGNC VGNC:36622
Rattus norvegicus UBXN1 RGD RGD:1309471
Canis familiaris UBXN1 VGNC VGNC:48095
Macaca mulatta UBXN1 VGNC VGNC:79135
Felis catus UBXN1 VGNC VGNC:66790
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