2. Gene
  3. PLAA - phospholipase A2 activating protein Gene

PLAA - phospholipase A2 activating protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酶 A2 活化蛋白

种属: Homo sapiens

同用名: DOA1; PLAP; PLA2P; NDMSBA

基因 ID: 9373 | 基因类型: protein coding

关于 PLAA

Cytogenetic location: 9p21.2 Genomic coordinates (GRCh38): 9:26,903,372-26,947,242 (from NCBI)

This gene has 7 transcripts (splice variants), 209 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 6.9), bone marrow (RPKM 5.3) and 25 other tissues.

功能概要

预测启用泛素结合活性。参与细胞对脂多糖的反应；巨自噬；和磷脂酶 A2 活性的正调节。位于细胞质中；细胞外外泌体；和核。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ubiquitin binding activity. Involved in cellular response to lipopolysaccharide; macroautophagy; and positive regulation of Phospholipase A2 activity. Located in cytoplasm; extracellular exosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PLAA 基因产物(2)

mRNA Protein Name
NM_001031689.3 NP_001026859.1 phospholipase A-2-activating protein isoform 1
NM_001321546.2 NP_001308475.1 phospholipase A-2-activating protein isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18775313 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
28007986 GOA
involved in macroautophagy IMP
IMP: 通过突变表型推断
27753622 GOA
involved in positive regulation of phospholipase A2 activity IMP
IMP: 通过突变表型推断
28007986 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
27753622 GOA
located in extracellular exosome IDA
IDA: 通过直接分析推断
17076679 GOA
located in nucleus IDA
IDA: 通过直接分析推断
28007986 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLAA 蛋白结构

WD40

WD40: WD domain, G-beta repeat (13 - 46)

WD40

WD40: WD domain, G-beta repeat (61 - 98)

WD40

WD40: WD domain, G-beta repeat (104 - 138)

WD40

WD40: WD domain, G-beta repeat (142 - 179)

WD40

WD40: WD domain, G-beta repeat (181 - 217)

WD40

WD40: WD domain, G-beta repeat (221 - 259)

PFU

PFU: PFU (PLAA family ubiquitin binding) (345 - 459)

PUL

PUL: PUL domain (534 - 789)

  • 0
  • 200
  • 400
  • 600
  • 795 a.a.
蛋白主名 其他名称

phospholipase A-2-activating protein

DOA1 homolog

PLAA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PLAA Q9Y263 UBXN1 Homo sapiens Q04323
Y2H Prey Pooling
25416956
Intra PLAA Q9Y263 UBXN1 Homo sapiens Q04323
Validated Y2H
25416956
Intra PLAA Q9Y263 UBXN1 Homo sapiens Q04323-2
Y2H Prey Pooling
32296183
Intra PLAA Q9Y263 UBXN1 Homo sapiens Q04323-2
Y2H Array
32296183
Intra PLAA Q9Y263 VCP Homo sapiens P55072
Y2H Prey Pooling
32296183
Intra PLAA Q9Y263 VCP Homo sapiens P55072
Y2H Array
25416956
Intra PLAA Q9Y263 VCP Homo sapiens P55072
Y2H Array
32296183
Intra PLAA Q9Y263 VCP Homo sapiens P55072
Y2H Prey Pooling
25416956
Intra PLAA Q9Y263 KPNA4 Homo sapiens O00629
Y2H Prey Pooling
25416956
Intra PLAA Q9Y263 KPNA4 Homo sapiens O00629
Validated Y2H
25416956
Cross PLAA Q9Y263 q76353_9hiv1 Human immunodeficiency virus Q76353
Pull Down
22190034
Intra PLAA Q9Y263 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra PLAA Q9Y263 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies

NDMSBA

Plaa-Associated Neurodevelopmental Disorder

Plaand
Split-Hand/Foot Malformation 1

Ectrodactyly

Split Hand-Foot Malformation 1

SHFM1

Shfd1

Split-Hand Deformity

Split-Hand/Foot Malformation 1 With Or Without Deafness

Split-Hand/Foot Deformity 1

Ecd

Split Hand/Foot Malformation Type 1

Split Hand Foot Deformity 1

Split-Hand/Foot Malformation
Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To
Combined T And B Cell Immunodeficiency
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Conjugate Gaze Palsy

Palsy Of Conjugate Gaze

Supranuclear Ocular Palsy

Gaze Palsy
Peho Syndrome

Progressive Encephalopathy With Edema, Hypsarrhythmia, And Optic Atrophy

Infantile Cerebellooptic Atrophy

PEHO

Progressive Encephalopathy With Edema, Hypsarrhythmia And Optic Atrophy

Progressive Encephalopathy-Optic Atrophy Syndrome
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia

Pagetoid Amyotrophic Lateral Sclerosis

Pagetoid Neuroskeletal Syndrome

Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia

Multisystem Proteinopathy

Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone

Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement

Lower Motor Neuron Degeneration With Paget-Like Bone Disease

Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone

Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10636 PLAA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PLAA VGNC VGNC:44634
Bos taurus PLAA VGNC VGNC:32967
Rattus norvegicus PLAA RGD RGD:621245
Mus musculus PLAA MGD MGI:104810
Felis catus PLAA VGNC VGNC:68886
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