H3-5 - H3.5 histone Gene

中文名称：H3.5 组蛋白

种属: Homo sapiens

同用名: H3.5; H3.3C; H3F3C

关于 H3-5

功能概要

组蛋白是基本的核蛋白，负责真核生物染色体纤维的核小体结构。核小体由大约 146 bp 的 DNA 组成，包裹在由四种核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一种成对组成的组蛋白八聚体周围。染色质纤维通过接头组蛋白 H1 与核小体之间的 DNA 相互作用进一步压缩，形成更高阶的染色质结构。与大多数组蛋白基因不同，该基因包含内含子并且其 mRNA 是聚腺苷酸化的。该基因编码的蛋白质是一种不依赖于复制的组蛋白，是组蛋白 H3 家族的一员。[RefSeq 提供，2015 年 10 月]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Oct 2015]