DMAP1 - DNA methyltransferase 1 associated protein 1 Gene

中文名称：DNA 甲基转移酶 1 相关蛋白 1

种属: Homo sapiens

同用名: EAF2; SWC4; MEAF2; DNMAP1; DNMTAP1

关于 DMAP1

功能概要

该基因编码参与转录抑制或激活的几个不同复合物的亚基。编码的蛋白质可以独立抑制转录，并通过直接与 DNA 甲基转移酶 1 的 N 末端相互作用，靶向整个 S 期的复制焦点。在晚期 S 期，组蛋白去乙酰化酶 2 被添加到该复合物中，提供了一种使组蛋白去乙酰化的方法复制后转录失活的异染色质。编码的蛋白质也是 H4 复合物核小体乙酰转移酶的组成部分，并与转录辅抑制肿瘤易感基因 101 和促凋亡死亡相关蛋白 6 等相互作用。已经描述了编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA Methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among Others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]