DUSP7 - dual specificity phosphatase 7 Gene

中文名称：双特异性磷酸酶 7

种属: Homo sapiens

同用名: MKPX; PYST2

关于 DUSP7

功能概要

双特异性磷酸酶 (DUSP) 构成了 I 型基于半胱氨酸的蛋白酪氨酸磷酸酶超家族的一个大的异质亚群。 DUSP 的特征在于它们能够使酪氨酸和丝氨酸/苏氨酸残基去磷酸化。 DUSP7 属于一类 DUSP，称为 MKP，可使 MAPK (丝裂原活化蛋白激酶) 蛋白 ERK (参见 MIM 601795) 、JNK (参见 MIM 601158) 和 p38 (参见 MIM 600289) 去磷酸化，具有不同于个体的特异性 MKP 蛋白。 MKP 包含一个高度保守的 C 端催化结构域和一个 N 端 Cdc25 (参见 MIM 116947) 样 (CH2) 结构域。 MAPK 激活级联介导各种生理过程，包括细胞增殖、细胞凋亡、分化和应激反应 (Patterson 等人总结，2009 [PubMed 19228121]) 。[OMIM 提供，2009 年 12 月]

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine Phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, Apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]