CARM1 - coactivator associated arginine methyltransferase 1 Gene

中文名称：共激活因子相关精氨酸甲基转移酶 1

种属: Homo sapiens

同用名: PRMT4

基因 ID: 10498 | 基因类型: protein coding

关于 CARM1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,871,553-10,923,075 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 20.7), placenta (RPKM 17.2) and 25 other tissues.

功能概要

该基因属于蛋白质精氨酸甲基转移酶 (PRMT) 家族。编码的酶催化蛋白质精氨酰残基的胍基氮甲基化。该酶特异性作用于组蛋白和其他染色质相关蛋白，并参与基因表达的调节。该酶可能与其他蛋白质联合作用或在多蛋白质复合物中起作用，并可能在细胞类型特异性功能和细胞谱系规范中发挥作用。一个相关的假基因位于 9 号染色体上。[RefSeq 提供，2013 年 8 月]

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded Enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The Enzyme acts specifically on histones and Other chromatin-associated proteins and is involved in regulation of gene expression. The Enzyme may act in association with Other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]

CARM1 基因产物(5)

mRNA	Protein	Name
NM_199141.2	NP_954592.1	histone-arginine methyltransferase CARM1 isoform 1
XM_047438058.1	XP_047294014.1	histone-arginine methyltransferase CARM1 isoform X1
NM_001370088.1	NP_001357017.1	histone-arginine methyltransferase CARM1 isoform 2
NM_001370089.1	NP_001357018.1	histone-arginine methyltransferase CARM1 isoform 3
XM_011527638.3	XP_011525940.1	histone-arginine methyltransferase CARM1 isoform X2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	15471871	GOA
enables histone H3R17 methyltransferase activity	IDA IDA: 通过直接分析推断	15471871	GOA
enables histone H3R2 methyltransferase activity	IMP IMP: 通过突变表型推断	17898714	GOA
enables histone arginine N-methyltransferase activity	IDA IDA: 通过直接分析推断	23980157	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16938873	GOA
enables protein-arginine N-methyltransferase activity	IDA IDA: 通过直接分析推断	18495660	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	15471871	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of epithelial cell apoptotic process	IDA IDA: 通过直接分析推断	34480022	GOA
involved in positive regulation of transcription by RNA polymerase I	IDA IDA: 通过直接分析推断	15471871	GOA
involved in replication fork reversal	IDA IDA: 通过直接分析推断	33412112	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	15221992	GOA
is active in nuclear replication fork	IDA IDA: 通过直接分析推断	33412112	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15221992	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CARM1 蛋白结构

CARM1

PRMT5

0
100
200
300
400
500
608 a.a.

蛋白主名

其他名称

histone-arginine methyltransferase CARM1

protein arginine N-methyltransferase 4

CARM1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	CARM1	Q86X55	a0a1u8qn96_yerpe	Yersinia pestis	A0A1U8QN96	Y2H Array	21911467
种属内	CARM1	Q86X55	SMARCC1	Homo sapiens	Q92922	Anti Tag CoIP	24434208
种属内	CARM1	Q86X55	NUDT21	Homo sapiens	O43809	Anti Tag CoIP	23455924
种属内	CARM1	Q86X55	DNAJA3	Homo sapiens	Q96EY1	Y2H	23455924
种属内	CARM1	Q86X55	NCOA3	Homo sapiens	Q9Y6Q9	Anti Bait CoIP	16938873
种属内	CARM1	Q86X55	QKI	Homo sapiens	Q96PU8	Y2H	23455924
种属内	CARM1	Q86X55	CEBPB	Homo sapiens	P17676	Anti Bait CoIP	20111005
种属内	CARM1	Q86X55	CEBPB	Homo sapiens	P17676	Anti Tag CoIP	20111005
种属间	CARM1	Q86X55	CEBPB	Gallus gallus	Q05826	Anti Tag CoIP	20111005

种属间: 跨种属相互作用 种属内: 同种属相互作用

CARM1 抗体

目录号	产品名	应用	反应物种
HY-P80583	CARM1 Antibody (YA812)	WB, IP	Human, Mouse

关联疾病

疾病名称

别名

Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

Severe Congenital Encephalopathy Due To Mecp2 Mutation	Severe Neonatal-Onset Encephalopathy With Microcephaly
Encephalopathy, Neonatal Severe	Neonatal Severe Encephalopathy Due To Mecp2 Mutations
Mecp2-Related Severe Neonatal Encephalopathy	Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy
Severe Neonatal Encephalopathy Due To Mecp2 Mutations	ENS-MECP2
Encephalopathy, Neonatal, Severe

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-114965	TP-064	Inhibitor	99.61%	否
HY-111109	EZM 2302	Inhibitor	99.59%	否
HY-100565	SGC2085	Inhibitor	99.46%	否
HY-110137	Furamidine dihydrochloride	Inhibitor	≥99.0%	否
HY-12759	CARM1-IN-1	Inhibitor	≥95.0%	否
HY-15214	CARM1-IN-3	Inhibitor	98.90%	否
HY-15214A	CARM1-IN-3 dihydrochloride	Inhibitor	98.77%	否
HY-156152A	CARM1 degrader-1 hydrochloride	Degrader	/	否
HY-12759A	CARM1-IN-1 hydrochloride	Inhibitor	95.13%	否
HY-157388	CARM1/HDAC2-IN-1	Inhibitor	/	否
HY-100855	DC_C66	Inhibitor	/	否
HY-100565A	SGC2085 hydrochloride	Inhibitor	/	否
HY-110137A	Furamidine	Inhibitor	/	否
HY-136809	PRMT6-IN-2		/	否
HY-156152	CARM1 degrader-1	Inhibitor	/	否
HY-156153	CARM1 degrader-2	Inhibitor	/	否
HY-158157	ZL-28-6	Inhibitor	/	否
HY-158158	CARM1-IN-5	Inhibitor	/	否
HY-161334	CARM1-IN-4		/	否
HY-163561	CARM1-IN-6	Inhibitor	/	否
HY-RS01926	CARM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01927	Carm1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01928	Carm1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-117927	EPZ0025654	Inhibitor	/	否
HY-W013500	(1-Nitroethene-1,2-diyl)dibenzene	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CARM1	VGNC	VGNC:60369
Bos taurus	CARM1	VGNC	VGNC:26767
Macaca mulatta	CARM1	VGNC	VGNC:70612
Canis familiaris	CARM1	VGNC	VGNC:38721
Mus musculus	CARM1	MGD	MGI:1913208
Rattus norvegicus	CARM1	RGD	RGD:1305879
Others	CARM1	NCBI

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