2. Gene
  3. QKI - QKI, KH domain containing RNA binding Gene

QKI - QKI, KH domain containing RNA binding Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 QKI， RNA 结合的 KH 结构域

种属: Homo sapiens

同用名: QK; Hqk; QK1; QK3; hqkI

基因 ID: 9444 | 基因类型: protein coding

关于 QKI

Cytogenetic location: 6q26 Genomic coordinates (GRCh38): 6:163,414,718-163,578,592 (from NCBI)

This gene has 17 transcripts (splice variants), 257 orthologues, 4 paralogues and is associated with 71 phenotypes. Broad expression in brain (RPKM 50.5), fat (RPKM 18.4) and 21 other tissues.

功能概要

该基因编码的蛋白质是一种 RNA 结合蛋白，可调节 pre-mRNA 剪接、mRNA 从细胞核输出、蛋白质翻译和 mRNA 稳定性。编码的蛋白质参与髓鞘形成和少突胶质细胞分化，并可能在精神分裂症中发挥作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 7 月]

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

QKI 基因产物(5)

mRNA Protein Name
NM_001301085.2 NP_001288014.1 protein quaking isoform 5
NM_006775.3 NP_006766.1 protein quaking isoform 1
NM_206853.3 NP_996735.1 protein quaking isoform 2
NM_206854.3 NP_996736.1 protein quaking isoform 3
NM_206855.3 NP_996737.1 protein quaking isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables internal N(7)-methylguanine-containing RNA reader activity IDA
IDA: 通过直接分析推断
37379838 GOA
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
22398723 GOA
enables mRNA binding IDA
IDA: 通过直接分析推断
25768908 GOA
enables miRNA binding IDA
IDA: 通过直接分析推断
31792053 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular mRNA localization IDA
IDA: 通过直接分析推断
37379838 GOA
involved in mRNA stabilization IDA
IDA: 通过直接分析推断
32732889 GOA
involved in mRNA transport IDA
IDA: 通过直接分析推断
37379838 GOA
involved in negative regulation of angiogenesis IDA
IDA: 通过直接分析推断
32732889 GOA
involved in negative regulation of macrophage differentiation IDA
IDA: 通过直接分析推断
22398723 GOA
involved in negative regulation of miRNA catabolic process IDA
IDA: 通过直接分析推断
31792053 GOA
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
31829086 GOA
involved in negative regulation of type I interferon production IDA
IDA: 通过直接分析推断
31829086 GOA
involved in regulation of epithelial to mesenchymal transition IDA
IDA: 通过直接分析推断
25768908 GOA
involved in regulation of mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
27029405 GOA
involved in regulation of macrophage differentiation IDA
IDA: 通过直接分析推断
27029405 GOA
involved in spliceosome-depend formation of circular RNA IDA
IDA: 通过直接分析推断
25768908 GOA
involved in vascular associated smooth muscle cell differentiation IDA
IDA: 通过直接分析推断
31331967 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
37379838 GOA
is active in cytosol IDA
IDA: 通过直接分析推断
37379838 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
37379838 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

QKI 蛋白结构

KH_1

KH_1: KH domain (97 - 126)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
蛋白主名 其他名称

protein quaking

QKI/LOC100132735 fusion

QKI 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra QKI Q96PU8 MALT1 Homo sapiens Q9UDY8
Anti Bait CoIP
31774199
Intra QKI Q96PU8 CARM1 Homo sapiens Q86X55
Anti Tag CoIP
23455924
Intra QKI Q96PU8 NABP1 Homo sapiens Q96AH0
Validated Y2H
25416956
Intra QKI Q96PU8 NABP1 Homo sapiens Q96AH0
Y2H Array
25416956
Intra QKI Q96PU8 HNRNPK Homo sapiens P61978
Pull Down
16713569
Intra QKI Q96PU8 HNRNPK Homo sapiens P61978
Y2H Array
25416956
Intra QKI Q96PU8 HNRNPK Homo sapiens P61978
Y2H Array
29892012
Intra QKI Q96PU8 PTBP1 Homo sapiens P26599
Pull Down
16713569
Intra QKI Q96PU8 PTBP1 Homo sapiens P26599
Y2H
22365833
Intra QKI Q96PU8 HNRNPLL Homo sapiens Q8WVV9
Y2H Prey Pooling
25416956
Intra QKI Q96PU8 HNRNPLL Homo sapiens Q8WVV9
Y2H Array
25416956
Intra QKI Q96PU8 SNRPA Homo sapiens P09012
Y2H Array
25416956
Intra QKI Q96PU8 RBPMS Homo sapiens Q93062
Pull Down
16713569
Intra QKI Q96PU8 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
Intra QKI Q96PU8 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra QKI Q96PU8 RBM11 Homo sapiens P57052
Validated Y2H
25416956
Intra QKI Q96PU8 RBM11 Homo sapiens P57052
Y2H Prey Pooling
25416956
Intra QKI Q96PU8 RBFOX2 Homo sapiens O43251
Anti Tag CoIP
33961781
Intra QKI Q96PU8 RBFOX2 Homo sapiens O43251
Pull Down
16713569
Intra QKI Q96PU8 RBFOX2 Homo sapiens O43251
Y2H
22365833
Intra QKI Q96PU8 PCBP1 Homo sapiens Q15365
Y2H
16713569
Intra QKI Q96PU8 FUBP3 Homo sapiens Q96I24
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Angiocentric Glioma
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Pilomyxoid Astrocytoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11500 QKI Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta QKI VGNC VGNC:99431
Canis familiaris QKI VGNC VGNC:45232
Felis catus QKI VGNC VGNC:64456
Rattus norvegicus QKI RGD RGD:1584886
Mus musculus QKI MGD MGI:97837
Bos taurus QKI VGNC VGNC:33597
Others QKI NCBI
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