2. Gene
  3. HNRNPLL - heterogeneous nuclear ribonucleoprotein L like Gene

HNRNPLL - heterogeneous nuclear ribonucleoprotein L like Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：异质核核糖核蛋白 L 样

种属: Homo sapiens

同用名: SRRF; HNRPLL

基因 ID: 92906 | 基因类型: protein coding

关于 HNRNPLL

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:38,561,969-38,602,928 (from NCBI)

This gene has 12 transcripts (splice variants), 275 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 17.8), thyroid (RPKM 11.5) and 25 other tissues.

功能概要

HNRNPLL 是 T 细胞中激活诱导的选择性剪接的主要调节因子。特别是，它改变了 CD45 (PTPRC；MIM 151460) 的剪接，这是一种对 T 细胞发育和激活至关重要的酪氨酸磷酸酶 (Oberdoerffer 等人，2008 [PubMed 18669861]) 。[OMIM 提供，2008 年 8 月]

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine Phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]

HNRNPLL 基因产物(2)

mRNA Protein Name
NM_001142650.2 NP_001136122.1 heterogeneous nuclear ribonucleoprotein L-like isoform 2
NM_138394.4 NP_612403.2 heterogeneous nuclear ribonucleoprotein L-like isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mRNA binding IDA
IDA: 通过直接分析推断
18669861 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18669861 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of RNA splicing IDA
IDA: 通过直接分析推断
18669861 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HNRNPLL 蛋白结构

(78 - 130)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (185 - 242)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (352 - 407)

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  • 542 a.a.
蛋白主名 其他名称

heterogeneous nuclear ribonucleoprotein L-like

stromal RNA regulating factor

HNRNPLL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
HNRNPLL Q8WVV9 P0DTD1-PRO_0000449620 SARS-CoV-2 P0DTD1-PRO_0000449620
BLI
34159380
种属内
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978
Y2H Array
29892012
种属内
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978
Validated Y2H
25416956
种属内
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978
Y2H Prey Pooling
25416956
种属内
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978
Y2H Array
25416956
种属内
HNRNPLL Q8WVV9 RHOXF2 Homo sapiens Q9BQY4
Validated Y2H
25416956
种属内
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978-2
Validated Y2H
26871637
种属内
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978-2
Y2H Array
26871637
种属内
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978-2
Y2H Array
32296183
种属内
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
26871637
种属内
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
32296183
种属内
HNRNPLL Q8WVV9 MDFI Homo sapiens Q99750
Validated Y2H
25416956
种属内
HNRNPLL Q8WVV9 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
25416956
种属内
HNRNPLL Q8WVV9 THAP1 Homo sapiens Q9NVV9
Validated Y2H
25416956
种属内
HNRNPLL Q8WVV9 THAP1 Homo sapiens Q9NVV9
Y2H Array
25416956
种属内
HNRNPLL Q8WVV9 DAB1 Homo sapiens O75553
Validated Y2H
25416956
种属内
HNRNPLL Q8WVV9 DAB1 Homo sapiens O75553
Y2H Array
25416956
种属内
HNRNPLL Q8WVV9 QKI Homo sapiens Q96PU8
Anti Tag CoIP
33961781
种属内
HNRNPLL Q8WVV9 QKI Homo sapiens Q96PU8
Validated Y2H
25416956
种属内
HNRNPLL Q8WVV9 BOLL Homo sapiens Q8N9W6
Y2H Array
31515488
种属内
HNRNPLL Q8WVV9 BOLL Homo sapiens Q8N9W6
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06275 HNRNPLL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HNRNPLL MGD MGI:1919942
Bos taurus HNRNPLL VGNC VGNC:29898
Rattus norvegicus HNRNPLL RGD RGD:1305861
Canis familiaris HNRNPLL VGNC VGNC:41733
Felis catus HNRNPLL VGNC VGNC:62827
Macaca mulatta HNRNPLL VGNC VGNC:73441
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