2. Gene
  3. NABP1 - nucleic acid binding protein 1 Gene

NABP1 - nucleic acid binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核酸结合蛋白 1

种属: Homo sapiens

同用名: SSB2; OBFC2A; SOSS-B2; NABP1-OT1

基因 ID: 64859 | 基因类型: protein coding

关于 NABP1

Cytogenetic location: 2q32.3 Genomic coordinates (GRCh38): 2:191,678,136-191,686,943 (from NCBI)

This gene has 16 transcripts (splice variants), 205 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in appendix (RPKM 17.5), spleen (RPKM 12.9) and 21 other tissues.

功能概要

单链 DNA (ssDNA) 结合蛋白，如 OBFC2A，在各种 DNA 代谢过程中普遍存在且必不可少，包括复制、重组以及损伤检测和修复 (Richard 等人，2008 [PubMed 18449195]) .[OMIM 提供，2008 年 6 月]

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

NABP1 基因产物(2)

mRNA Protein Name
NM_001031716.5 NP_001026886.1 SOSS complex subunit B2 isoform 1
NM_001254736.3 NP_001241665.1 SOSS complex subunit B2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19683501 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
19683501 GOA
involved in DNA repair IMP
IMP: 通过突变表型推断
19683501 GOA
involved in double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
19683501 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
19605351 GOA
involved in mitotic G2/M transition checkpoint IDA
IDA: 通过直接分析推断
19683501 GOA
involved in mitotic G2/M transition checkpoint IMP
IMP: 通过突变表型推断
19683501 GOA
involved in response to ionizing radiation IMP
IMP: 通过突变表型推断
19605351 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SOSS complex IDA
IDA: 通过直接分析推断
18449195 GOA
part of SOSS complex IPI
IPI: 通过物理相互作用推断
19683501 GOA
located in nucleus IDA
IDA: 通过直接分析推断
19683501 GOA
located in site of double-strand break IDA
IDA: 通过直接分析推断
19683501 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NABP1 蛋白结构

tRNA_anti-codon

tRNA_anti-codon: OB-fold nucleic acid binding domain (31 - 88)

  • 0
  • 100
  • 204 a.a.
蛋白主名 其他名称

SOSS complex subunit B2

NABP1 3'UTR overlapping transcript 1

NABP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NABP1 Q96AH0 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra NABP1 Q96AH0 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra NABP1 Q96AH0 MKRN3 Homo sapiens Q13064
Validated Y2H
25416956
Intra NABP1 Q96AH0 INTS3 Homo sapiens Q68E01
Anti Bait CoIP
19683501
Intra NABP1 Q96AH0 INTS3 Homo sapiens Q68E01
Pull Down
19683501
Intra NABP1 Q96AH0 TRIM7 Homo sapiens Q9C029
Validated Y2H
32296183
Intra NABP1 Q96AH0 TRIM7 Homo sapiens Q9C029
Y2H Prey Pooling
32296183
Intra NABP1 Q96AH0 TRIM7 Homo sapiens Q9C029
Y2H Array
32296183
Intra NABP1 Q96AH0 PURB Homo sapiens Q96QR8
Validated Y2H
32296183
Intra NABP1 Q96AH0 PURB Homo sapiens Q96QR8
Y2H Array
32296183
Intra NABP1 Q96AH0 PURB Homo sapiens Q96QR8
Y2H Prey Pooling
32296183
Intra NABP1 Q96AH0 COPS3 Homo sapiens Q9UNS2
Validated Y2H
32296183
Intra NABP1 Q96AH0 COPS3 Homo sapiens Q9UNS2
Y2H Prey Pooling
32296183
Intra NABP1 Q96AH0 COPS3 Homo sapiens Q9UNS2
Y2H Array
32296183
Intra NABP1 Q96AH0 TFCP2 Homo sapiens Q12800
Y2H Array
25416956
Intra NABP1 Q96AH0 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
25416956
Intra NABP1 Q96AH0 RBMX Homo sapiens P38159
Y2H Array
25416956
Intra NABP1 Q96AH0 RBMX Homo sapiens P38159
Y2H Array
32296183
Intra NABP1 Q96AH0 RBMX Homo sapiens P38159
Y2H Prey Pooling
25416956
Intra NABP1 Q96AH0 RBMX Homo sapiens P38159
Validated Y2H
25416956
Intra NABP1 Q96AH0 RBMX Homo sapiens P38159
Y2H Prey Pooling
32296183
Intra NABP1 Q96AH0 QKI Homo sapiens Q96PU8
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Cholestasis, Intrahepatic, Of Pregnancy 3

ICP3

Cholestasis, Intrahepatic, Of Pregnancy, 3

Intrahepatic Cholestasis Of Pregnancy 3

Pregnancy Related Cholestasis 3

Cholestasis Of Pregnancy, Intrahepatic 3

Cholestasis, Intrahepatic, Of Pregnancy, Type 3
Splenic Manifestation Of Leukemia

Splenic Leukemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08998 NABP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NABP1 RGD RGD:1306658
Bos taurus NABP1 VGNC VGNC:31859
Mus musculus NABP1 MGD MGI:1923258
Felis catus NABP1 VGNC VGNC:63706
Macaca mulatta NABP1 VGNC VGNC:75025
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