1. Gene
  2. TRIM7 - tripartite motif containing 7 Gene

TRIM7 - tripartite motif containing 7 Gene

中文名称:含三方基序 7

种属: Homo sapiens

同用名: GNIP; RNF90

基因 ID: 81786 | 基因类型: protein coding

关于 TRIM7

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:181,193,924-181,205,196 (from NCBI)

This gene has 7 transcripts (splice variants), 178 orthologues and 80 paralogues. Biased expression in skin (RPKM 5.6), esophagus (RPKM 2.8) and 8 other tissues.

功能概要

由该基因编码的蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1、一个 B-box 类型 2 和一个卷曲螺旋区域。该蛋白质定位于细胞核和细胞质,可能代表参与糖原合成的启动。可变剪接导致多个转录本变体。[RefSeq 提供,2013 年 7 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to both the nucleus and the cytoplasm, and may represent a participant in the initiation of glycogen synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

TRIM7 基因产物(6)

mRNA Protein Name
NM_033342.4 NP_203128.1 E3 ubiquitin-protein ligase TRIM7 isoform 4
NM_203293.3 NP_976038.1 E3 ubiquitin-protein ligase TRIM7 isoform 1
NM_203294.2 NP_976039.1 E3 ubiquitin-protein ligase TRIM7 isoform 3
NM_203295.2 NP_976040.1 E3 ubiquitin-protein ligase TRIM7 isoform 3
NM_203296.2 NP_976041.1 E3 ubiquitin-protein ligase TRIM7 isoform 3
NM_203297.2 NP_976042.1 E3 ubiquitin-protein ligase TRIM7 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
35893676 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
35893676 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
35893676 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
11331580 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11331580 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRIM7 蛋白结构

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (29 - 81)

zf-B_box

zf-B_box: B-box zinc finger (128 - 166)

PRY

PRY: SPRY-associated domain (344 - 392)

SPRY

SPRY: SPRY domain (394 - 502)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 511 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase TRIM7

RING finger protein 90

TRIM7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRIM7 Q9C029 CFL2 Homo sapiens Q9Y281
Validated Y2H
32296183
种属内
TRIM7 Q9C029 IRAK4 Homo sapiens Q9NWZ3
Validated Y2H
32296183
种属内
TRIM7 Q9C029 CTNNAL1 Homo sapiens Q9UBT7
Validated Y2H
32296183
种属内
TRIM7 Q9C029 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
种属内
TRIM7 Q9C029 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
种属内
TRIM7 Q9C029 RSPH14 Homo sapiens Q9UHP6
Validated Y2H
32296183
种属内
TRIM7 Q9C029 MAD2L2 Homo sapiens Q9UI95
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Noonan Syndrome 7

NS7

Noonan Syndrome, Type 7

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus TRIM7 VGNC VGNC:36351
Felis catus TRIM7 VGNC VGNC:66552
Macaca mulatta TRIM7 VGNC VGNC:79022
Rattus norvegicus TRIM7 RGD RGD:1307328
Mus musculus TRIM7 MGD MGI:2137353
Canis familiaris TRIM7 VGNC VGNC:47836
Others TRIM7 NCBI