2. Gene
  3. CTNNAL1 - catenin alpha like 1 Gene

CTNNAL1 - catenin alpha like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：连环蛋白 alpha like 1

种属: Homo sapiens

同用名: ACRP; CLLP; alpha-CATU

基因 ID: 8727 | 基因类型: protein coding

关于 CTNNAL1

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:108,942,577-109,013,499 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 4 paralogues. Broad expression in adrenal (RPKM 101.6), ovary (RPKM 57.7) and 22 other tissues.

功能概要

预测启用肌动蛋白丝结合活性和钙粘蛋白结合活性。作用于 Rho 蛋白信号转导的上游或内部。位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable actin filament binding activity and cadherin binding activity. Acts upstream of or within Rho protein signal transduction. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CTNNAL1 基因产物(2)

mRNA Protein Name
NM_001286974.2 NP_001273903.1 alpha-catulin isoform b
NM_003798.4 NP_003789.1 alpha-catulin isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21115837 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Rho protein signal transduction IDA
IDA: 通过直接分析推断
12270917 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
12270917 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CTNNAL1 蛋白结构

Vinculin

Vinculin: Vinculin family (31 - 277)

Vinculin

Vinculin: Vinculin family (342 - 525)

Vinculin

Vinculin: Vinculin family (577 - 675)

  • 0
  • 200
  • 400
  • 600
  • 734 a.a.
蛋白主名 其他名称

alpha-catulin

alpha-catenin-related protein

CTNNAL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CTNNAL1 Q9UBT7 TRIM7 Homo sapiens Q9C029
Y2H Prey Pooling
32296183
Intra CTNNAL1 Q9UBT7 TRIM7 Homo sapiens Q9C029
Y2H Array
32296183
Intra CTNNAL1 Q9UBT7 DMD Homo sapiens P11532
Y2H Prey Pooling
32296183
Intra CTNNAL1 Q9UBT7 DMD Homo sapiens P11532
Y2H Array
32296183
Intra CTNNAL1 Q9UBT7 DMD Homo sapiens P11532
Validated Y2H
25416956
Intra CTNNAL1 Q9UBT7 DMD Homo sapiens P11532
Y2H Prey Pooling
25416956
Intra CTNNAL1 Q9UBT7 DMD Homo sapiens P11532
Anti Tag CoIP
21115837
Intra CTNNAL1 Q9UBT7 DMD Homo sapiens P11532
TAP
21115837
Intra CTNNAL1 Q9UBT7 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Prey Pooling
32296183
Intra CTNNAL1 Q9UBT7 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
32296183
Intra CTNNAL1 Q9UBT7 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
32296183
Intra CTNNAL1 Q9UBT7 ZBED1 Homo sapiens O96006
Y2H Array
32296183
Intra CTNNAL1 Q9UBT7 ZBED1 Homo sapiens O96006
Y2H Prey Pooling
32296183
Intra CTNNAL1 Q9UBT7 DTNB Homo sapiens O60941
TAP
21115837
Intra CTNNAL1 Q9UBT7 BRME1 Homo sapiens Q0VDD7
Validated Y2H
25416956
Intra CTNNAL1 Q9UBT7 BRME1 Homo sapiens Q0VDD7
Y2H Prey Pooling
25416956
Intra CTNNAL1 Q9UBT7 CBY2 Homo sapiens Q8NA61
Y2H Prey Pooling
25416956
Intra CTNNAL1 Q9UBT7 SERTAD3 Homo sapiens Q9UJW9
Validated Y2H
32296183
Intra CTNNAL1 Q9UBT7 SERTAD3 Homo sapiens Q9UJW9
Y2H Array
32296183
Intra CTNNAL1 Q9UBT7 SERTAD3 Homo sapiens Q9UJW9
Y2H Prey Pooling
32296183
Intra CTNNAL1 Q9UBT7 DTNA Homo sapiens Q9Y4J8
Far-WB
21115837
Intra CTNNAL1 Q9UBT7 DTNA Homo sapiens Q9Y4J8
TAP
21115837
Intra CTNNAL1 Q9UBT7 DTNA Homo sapiens Q9Y4J8
Anti Tag CoIP
21115837
Intra CTNNAL1 Q9UBT7 DTNA Homo sapiens Q9Y4J8
Pull Down
21115837
Intra CTNNAL1 Q9UBT7 USH1C Homo sapiens Q9Y6N9
Validated Y2H
25416956
Intra CTNNAL1 Q9UBT7 PLCB2 Homo sapiens Q00722
Far-WB
21115837
Intra CTNNAL1 Q9UBT7 PLCB2 Homo sapiens Q00722
TAP
21115837
Intra CTNNAL1 Q9UBT7 RNF135 Homo sapiens Q8IUD6
Y2H Prey Pooling
32296183
Intra CTNNAL1 Q9UBT7 RNF135 Homo sapiens Q8IUD6
Y2H Array
32296183
Intra CTNNAL1 Q9UBT7 RNF135 Homo sapiens Q8IUD6
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1

Eec Syndrome

Rudiger Syndrome 1

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1

EEC1

Eec Syndrome 1

Eec Syndrome-1

Walker-Clodius Syndrome

Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome

Eec

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome

Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome

Ectrodactyly-Cleft Lip/Palate Syndrome

Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate

Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome

Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome

Ectrodactyly-Cleft Lip-Palate Syndrome

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness

Ovarian Dysgenesis With Sensorineural Deafness

Gonadal Dysgenesis, Xx Type

Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance

Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance

Xx Gonodal Dysgenesis-Deafness Syndrome

Xx Gonodal Dysgenesis-Hearing Loss Syndrome

Gonadal Dysgenesis Xx Type Deafness
Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03305 CTNNAL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CTNNAL1 MGD MGI:1859649
Bos taurus CTNNAL1 VGNC VGNC:27801
Rattus norvegicus CTNNAL1 RGD RGD:1311434
Felis catus CTNNAL1 VGNC VGNC:61255
Canis familiaris CTNNAL1 VGNC VGNC:39699
Macaca mulatta CTNNAL1 VGNC VGNC:71544
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