PURB - purine rich element binding protein B Gene

中文名称：富嘌呤元素结合蛋白 B

种属: Homo sapiens

同用名: PURBETA

关于 PURB

功能概要

该基因产物是一种序列特异性的单链 DNA 结合蛋白。它优先结合称为 PUR 的富含嘌呤元素的单链，PUR 存在于从酵母到人类的各种真核生物的复制起点和基因侧翼区域。因此，它与 DNA 复制和转录的控制有关。该基因的缺失与骨髓增生异常综合征和急性骨髓性白血病有关。[RefSeq 提供，2008 年 7 月]

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]