2. Gene
  3. INTS3 - integrator complex subunit 3 Gene

INTS3 - integrator complex subunit 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：整合复合体亚基 3

种属: Homo sapiens

同用名: INT3; SOSSA; SOSS-A; C1orf60; C1orf193

基因 ID: 65123 | 基因类型: protein coding

关于 INTS3

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,728,050-153,774,808 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele and 200 orthologues. Ubiquitous expression in testis (RPKM 20.6), ovary (RPKM 17.9) and 25 other tissues.

功能概要

该基因编码的蛋白质可以与人类单链 DNA 结合蛋白 1 或 2 (hSSB1 和 hSSB2) 和其他蛋白质形成复合物，以介导基因组稳定性和 DNA 损伤反应。编码的蛋白质也是多蛋白复合物的一部分，该复合物与 RNA 聚合酶 II 大亚基的 C 末端结构域相互作用，以帮助调节 U1 和 U2 小核 RNA 的加工。[RefSeq 提供，2016 年 5 月]

The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]

INTS3 基因产物(2)

mRNA Protein Name
NM_001324475.2 NP_001311404.1 integrator complex subunit 3
NM_023015.5 NP_075391.3 integrator complex subunit 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16239144 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
19683501 GOA
involved in DNA repair IMP
IMP: 通过突变表型推断
19605351 GOA
involved in double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
19683501 GOA
involved in mitotic G2/M transition checkpoint IDA
IDA: 通过直接分析推断
19683501 GOA
involved in mitotic G2/M transition checkpoint IMP
IMP: 通过突变表型推断
19683501 GOA
involved in response to ionizing radiation IMP
IMP: 通过突变表型推断
19605351 GOA
involved in snRNA processing IDA
IDA: 通过直接分析推断
16239144 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SOSS complex IDA
IDA: 通过直接分析推断
18449195 GOA
part of SOSS complex IPI
IPI: 通过物理相互作用推断
19683501 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
23904267 GOA
part of integrator complex IDA
IDA: 通过直接分析推断
16239144 GOA
located in nucleus IDA
IDA: 通过直接分析推断
19683501 GOA
located in site of double-strand break IDA
IDA: 通过直接分析推断
19683501 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

INTS3 蛋白结构

Ints3

Ints3: Integrator complex subunit 3 (270 - 498)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1042 a.a.
蛋白主名 其他名称

integrator complex subunit 3

SOSS complex subunit A

关联疾病

疾病名称 别名
Gand Syndrome

Mrd18

GAND

Mental Retardation, Autosomal Dominant 18

Autosomal Dominant Non-Syndromic Intellectual Disability 18

Autosomal Dominant Intellectual Developmental Disorder 18

Autosomal Dominant Mental Retardation 18
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-133702 Aniline-piperazine-C3-NH-Boc / 否
HY-RS06855 INTS3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus INTS3 VGNC VGNC:62944
Bos taurus INTS3 VGNC VGNC:30229
Macaca mulatta INTS3 VGNC VGNC:73659
Mus musculus INTS3 MGD MGI:2140050
Canis familiaris INTS3 VGNC VGNC:42052
Rattus norvegicus INTS3 RGD RGD:1304593
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