DNAJA3 - DnaJ heat shock protein family (Hsp40) member A3 Gene

中文名称：DnaJ 热休克蛋白家族 (Hsp40) 成员 A3

种属: Homo sapiens

同用名: TID1; HCA57; hTID-1

基因 ID: 9093 | 基因类型: protein coding

关于 DNAJA3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,425,868-4,456,775 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 282 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 19.3), kidney (RPKM 17.5) and 25 other tissues.

功能概要

该基因编码 DNAJ/HSP40 蛋白家族的一个成员。 DNAJ/HSP40 蛋白刺激 HSP70 伴侣的 ATP 酶活性，并在蛋白质折叠、降解和多聚体复合物组装中发挥关键作用。编码的蛋白质定位于线粒体并介导多种细胞过程，包括增殖、存活和凋亡信号转导。编码的蛋白质还通过与致癌蛋白 (包括 ErbB2 和 p53 肿瘤抑制蛋白) 的相互作用在肿瘤抑制中发挥关键作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the DNAJ/HSP40 protein family. DNAJ/HSP40 proteins stimulate the ATPase activity of HSP70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

DNAJA3 基因产物(3)

mRNA	Protein	Name
NM_001135110.3	NP_001128582.1	dnaJ homolog subfamily A member 3, mitochondrial isoform 2
NM_001286516.2	NP_001273445.1	dnaJ homolog subfamily A member 3, mitochondrial isoform 3
NM_005147.6	NP_005138.3	dnaJ homolog subfamily A member 3, mitochondrial isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	21106534	GOA
enables IkappaB kinase complex binding	IDA IDA: 通过直接分析推断	15601829	GOA
enables NF-kappaB binding	IPI IPI: 通过物理相互作用推断	15601829	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	16531398	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10411904	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	11679576	GOA
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	15601829	GOA
enables type II interferon receptor binding	IDA IDA: 通过直接分析推断	11679576	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	10411904	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	11927590	GOA
involved in negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	10411904	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	11927590	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	11719219	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	10411904	GOA
involved in negative regulation of protein kinase activity	IDA IDA: 通过直接分析推断	15601829	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	21106534	GOA
involved in negative regulation of type II interferon-mediated signaling pathway	IDA IDA: 通过直接分析推断	11679576	GOA
involved in neuromuscular junction development	IDA IDA: 通过直接分析推断	19038220	GOA
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	10411904	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: 通过直接分析推断	15520177	GOA
involved in protein folding	IDA IDA: 通过直接分析推断	16531398	GOA
involved in protein stabilization	IDA IDA: 通过直接分析推断	11927590	GOA
involved in response to type II interferon	IDA IDA: 通过直接分析推断	11679576	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with actin filament	IDA IDA: 通过直接分析推断	17588722	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	11679576	GOA
located in cytosol	IMP IMP: 通过突变表型推断	16531398	GOA
located in mitochondrial matrix	IDA IDA: 通过直接分析推断	10411904	GOA
located in mitochondrial nucleoid	IDA IDA: 通过直接分析推断	16531398	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	20053669	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11679576	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DNAJA3 蛋白结构

DnaJ

DnaJ_CXXCXGXG

DnaJ_C

0
100
200
300
400
480 a.a.

蛋白主名

其他名称

dnaJ homolog subfamily A member 3, mitochondrial

DnaJ (Hsp40) homolog, subfamily A, member 3

DNAJA3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DNAJA3	Q96EY1	STAT5B	Homo sapiens	P51692	Anti Bait CoIP	21106534
种属间	DNAJA3	Q96EY1	Ptch1	Mus musculus	Q61115	Anti Bait CoIP	17230190
种属间	DNAJA3	Q96EY1	Ptch1	Mus musculus	Q61115	Anti Tag CoIP	17230190
种属内	DNAJA3	Q96EY1	CARM1	Homo sapiens	Q86X55	Anti Tag CoIP	23455924
种属内	DNAJA3	Q96EY1	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
种属内	DNAJA3	Q96EY1	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
种属内	DNAJA3	Q96EY1	HTT	Homo sapiens	P42858	Y2H	17500595
种属间	DNAJA3	Q96EY1	Stat5b	Mus musculus	P42232	Y2H	21106534
种属内	DNAJA3	Q96EY1	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
种属内	DNAJA3	Q96EY1	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
种属内	DNAJA3	Q96EY1	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
种属内	DNAJA3	Q96EY1	KDM1A	Homo sapiens	O60341	Y2H	23455924
种属内	DNAJA3	Q96EY1	KDM1A	Homo sapiens	O60341	Anti Tag CoIP	23455924
种属内	DNAJA3	Q96EY1	PRMT6	Homo sapiens	Q96LA8	Y2H	23455924
种属内	DNAJA3	Q96EY1	PRMT6	Homo sapiens	Q96LA8	Anti Tag CoIP	23455924
种属内	DNAJA3	Q96EY1	ATXN1	Homo sapiens	P54253	Y2H	16713569

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Myasthenic Syndrome, Congenital, 12

Congenital Myasthenic Syndrome 12	CMS12
Myasthenic Syndrome, Congenital, With Tubular Aggregates 1	Cmsta1
Myasthenia, Congenital, 12, With Tubular Aggregates	Congenital Myasthenia 12 With Tubular Aggregates
Limb-Girdle Myasthenia With Tubular Aggregates	Myasthenia, Congenital, With Tubular Aggregates 1
Myasthenic Syndrome, Congenital, With Tubular Aggregates, 1

Alternating Esotropia

Codas Syndrome

Cerebral, Ocular, Dental, Auricular, And Skeletal Anomalies Syndrome	Cerebral, Ocular, Dental, Auricular, And Skeletal Syndrome
Cerebro-Oculo-Dento-Auriculo-Skeletal Syndrome	Cerebrooculodentoauriculoskeletal Syndrome
CODASS	Cerebral, Ocular, Dental, Auricular, Skeletal Syndrome

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Congenital Myasthenic Syndrome

Congenital Myasthenia	Congenital Myasthenic Syndromes
Cms	Myasthenic Syndromes, Congenital
Myasthenic Syndromes Congenital	Myasthenic Syndrome, Congenital
Congenital Myasthenic Syndrome Ib	Congenital And Developmental Myasthenia
Developmental Myasthenia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03859	DNAJA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	DNAJA3	VGNC	VGNC:99506
Felis catus	DNAJA3	VGNC	VGNC:80564
Mus musculus	DNAJA3	MGD	MGI:1933786
Rattus norvegicus	DNAJA3	RGD	RGD:1306527
Canis familiaris	DNAJA3	VGNC	VGNC:49081

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DNAJA3 - DnaJ heat shock protein family (Hsp40) member A3 Gene

关于 DNAJA3

功能概要

DNAJA3 基因产物(3)

DNAJA3 蛋白结构

DNAJA3 蛋白互作信息

关联疾病

直系同源

热门区域

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DNAJA3 - DnaJ heat shock protein family (Hsp40) member A3 Gene

关于 DNAJA3

功能概要

DNAJA3 基因产物(3)

DNAJA3 蛋白结构

DNAJA3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z