2. Cell Cycle/DNA Damage Epigenetics
  3. Histone Methyltransferase HDAC
  4. CARM1/HDAC2-IN-1

CARM1/HDAC2-IN-1 (化合物 CH-1) 是一种抗 CARM1 和 HDAC2 的双抑制剂，IC50 值分别是 3.71 nM 和 4.07 nM。CARM1/HDAC2-IN-1 具有抗肿瘤活性。

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CARM1/HDAC2-IN-1 Chemical Structure

CARM1/HDAC2-IN-1 Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥2450
4 - 6 周
5 mg 现货 4 - 6 周
10 mg 现货 4 - 6 周
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

CARM1/HDAC2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CARM1/HDAC2-IN-1 (compound CH-1) is a dual inhibitor against CARM1 and HDAC2, with IC50 values of 3.71 nM and 4.07 nM, respectively. CARM1/HDAC2-IN-1 possesses antitumor activity[1].

IC50 & Target[1]

CARM1

3.71 nM (IC50)

HDAC2

4.07 nM (IC50)

体外研究
(In Vitro)

CARM1/HDAC2-IN-1 可以抑制人前列腺癌细胞 DU145，RM1，LAPC4，22RV1 和 PC-3 的增殖，IC50 值分别是 0.09 μM，0.71 μM，0.68 μM，0.95 μM 和 0.43 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CARM1/HDAC2-IN-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: DU145, RM1, LAPC4, 22RV1 and PC-3
Concentration: ＜1 μM
Incubation Time: 72 h
Result: Reduced proliferations of human prostate cancer cells.
体内研究
(In Vivo)

CARM1/HDAC2-IN-1（腹腔注射；0-20 mg/kg，每四天注射一次，一共注射六次）具有与剂量相关的体内抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

622.76

Formula

C35H42N8O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CARM1/HDAC2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CARM1/HDAC2-IN-1Histone MethyltransferaseHDACHistone deacetylasesCARM1PRMTsHDAC2prostate cancerantiproliferativeantitumorDU145BALB/c miceInhibitorinhibitorinhibit

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产品名称：
CARM1/HDAC2-IN-1
目录号：
HY-157388
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