2. Epigenetics
  3. Histone Methyltransferase
  4. CARM1-IN-5

CARM1-IN-5 (Compound 17e) 是 CARM1 的高效选择性抑制剂 (IC50= 2 nM)。CARM1-IN-5 通过直接与 CARM1 相互作用，有效阻止其对底物蛋白进行甲基化。CARM1-IN-5 对黑色素瘤细胞系具有显著的抗增殖作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CARM1-IN-5 Chemical Structure

CARM1-IN-5 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CARM1-IN-5 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CARM1-IN-5 (Compound 17e) is a potent and selective inhibitor of CARM1 (IC50= 2 nM). CARM1-IN-5 effectively prevents CARM1 from methylating substrate proteins by directly interacting with CARM1. CARM1-IN-5 exhibits significant antiproliferative effects on melanoma cell lines[1].

体外研究
(In Vitro)

CARM1-IN-5 对 CARM1 具有选择性。IC50 分别为 2 ± 1 nM (CARM1), 213 ± 45 nM (PRMT1), 942 ± 78 nM (PRMT3), 64 ± 9 nM (PRMT6), 73 ± 8 nM (PRMT8), >100,000 nM (PRMT5), >100,000 nM (PRMT7)[1]。
CARM1-IN-5 对两种黑色素瘤细胞系的抗增殖活性为 IC50 = 0.55 ± 0.03 μM (A375); 1.74 ± 0.07μM (A2058)[1]。
CARM1-IN-5 (0-5 μM; 72 h) 可以进入 A375 Cells 并直接与 CARM1 结合。可以通过抑制 CARM1 的甲基转移酶活性，在细胞环境中影响 CARM1 底物的不对称二甲基化水平[1]。



体外代谢稳定性[1]

t1/2 (min) Cl (mL/min/kg)
41.5 132

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CARM1-IN-5 相关抗体:

Western Blot Analysis[1]

Cell Line: A375 Cells
Concentration: 0; 0.3; 0.6; 1.2; 2.5; 5μM
Incubation Time: 72h
Result: Enhanced protein thermal stability of CARM1 in a concentration-dependent manner.
Reduced asymmetric dimethyl-PABP1 and overall aDMA levels in a dose-dependent manner.
体内研究
(In Vivo)

CARM1-IN-5 (i.p.; 10 mg/kg/day 和 25 mg/kg/day; 14 天) 显著抑制 BALB/c 皮下移植 A375 的裸鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice bearing subcutaneous A375 xenograft [1]
Dosage: 10 mg/kg/daily; 25 mg/kg/daily for 14 days
Administration: i.p.
Result: TGI was 63% (25 mg/kg) and 55% (10 mg/kg).
Significantly reduced asymmetric dimethylation by western blotting.
分子量

431.98

Formula

C22H26ClN3O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CARM1-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CARM1-IN-5Histone MethyltransferaseAntitumor activityhigh selectivitycancerBALB/c nude miceMelanomaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CARM1-IN-5
目录号：
HY-158158
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z