PSMB7 - proteasome 20S subunit beta 7 Gene

中文名称：蛋白酶体 20S 亚基 beta 7

种属: Homo sapiens

关于 PSMB7

功能概要

蛋白酶体是一种多催化蛋白酶复合物，具有高度有序的环状 20S 核心结构。核心结构由 28 个不同亚基的 4 个环组成； 2 个环由 7 个α亚基组成，2 个环由 7 个β亚基组成。蛋白酶体以高浓度分布在整个真核细胞中，并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。编码的蛋白质是蛋白酶体 B 型家族的成员，也称为 T1B 家族，是蛋白酶体中的 20S 核心β亚基。这种催化亚基的表达被 γ 干扰素下调，并且需要蛋白水解加工才能产生成熟的亚基。该基因的假基因位于 14 号染色体的长臂上。[RefSeq 提供，2012 年 7 月]

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the Proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the Proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]