1. Gene
  2. PSMB6 - proteasome 20S subunit beta 6 Gene

PSMB6 - proteasome 20S subunit beta 6 Gene

中文名称:蛋白酶体 20S 亚基 6

种属: Homo sapiens

同用名: LMPY; DELTA

基因 ID: 5694 | 基因类型: protein coding

关于 PSMB6

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,796,164-4,798,495 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 18 paralogues. Ubiquitous expression in placenta (RPKM 53.0), heart (RPKM 51.7) and 25 other tissues.

功能概要

蛋白酶体是一种多催化蛋白酶复合物,具有高度有序的环状 20S 核心结构。核心结构由 28 个不同亚基的 4 个环组成; 2 个环由 7 个α亚基组成,2 个环由 7 个β亚基组成。蛋白酶体以高浓度分布在整个真核细胞中,并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。编码的蛋白质是蛋白酶体 B 型家族的成员,也称为 T1B 家族,是蛋白酶体中的 20S 核心β亚基。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2012 年 7 月]

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the Proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the Proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PSMB6 基因产物(2)

mRNA Protein Name
NM_001270481.2 NP_001257410.1 proteasome subunit beta type-6 isoform 2
NM_002798.3 NP_002789.1 proteasome subunit beta type-6 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14733938 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
34711951 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
34711951 GOA
part of proteasome complex IDA
IDA: 通过直接分析推断
17323924 GOA
part of proteasome core complex IDA
IDA: 通过直接分析推断
34711951 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PSMB6 蛋白结构

Proteasome

Proteasome: Proteasome subunit (31 - 212)

  • 0
  • 100
  • 200
  • 239 a.a.
蛋白主名 其他名称

proteasome subunit beta type-6

PSY large multifunctional protease Y

PSMB6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PSMB6 P28072 NDOR1 Homo sapiens Q9UHB4
Validated Y2H
32296183
Intra PSMB6 P28072 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra PSMB6 P28072 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra PSMB6 P28072 HTT Homo sapiens P42858
Y2H Array
32814053
Intra PSMB6 P28072 POMP Homo sapiens Q9Y244
Anti Tag CoIP
35271311
Intra PSMB6 P28072 POMP Homo sapiens Q9Y244
Y2H
14733938
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Felis catus PSMB6 VGNC VGNC:99326
Rattus norvegicus PSMB6 RGD RGD:61881
Bos taurus PSMB6 VGNC VGNC:33450
Canis familiaris PSMB6 VGNC VGNC:45098
Mus musculus PSMB6 MGD MGI:104880
Macaca mulatta PSMB6 VGNC VGNC:104644
Others PSMB6 NCBI