1. Gene
  2. GRIP1 - glutamate receptor interacting protein 1 Gene

GRIP1 - glutamate receptor interacting protein 1 Gene

中文名称:谷氨酸受体相互作用蛋白 1

种属: Homo sapiens

同用名: GRIP; FRASRS3

基因 ID: 23426 | 基因类型: protein coding

关于 GRIP1

Cytogenetic location: 12q14.3 Genomic coordinates (GRCh38): 12:66,347,431-67,069,338 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in placenta (RPKM 1.6), skin (RPKM 1.5) and 23 other tissues.

功能概要

该基因编码谷氨酸受体相互作用蛋白家族的一个成员。编码的支架蛋白结合并介导许多跨膜蛋白的运输和膜组织。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供,2010 年 5 月]

This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]

GRIP1 基因产物(11)

mRNA Protein Name
NM_001178074.2 NP_001171545.1 glutamate receptor-interacting protein 1 isoform 2
NM_001366722.1 NP_001353651.1 glutamate receptor-interacting protein 1 isoform 3
NM_001366723.1 NP_001353652.1 glutamate receptor-interacting protein 1 isoform 4
NM_001366724.1 NP_001353653.1 glutamate receptor-interacting protein 1 isoform 5
NM_001379345.1 NP_001366274.1 glutamate receptor-interacting protein 1 isoform 6
NM_001379346.1 NP_001366275.1 glutamate receptor-interacting protein 1 isoform 7
NM_001379347.1 NP_001366276.1 glutamate receptor-interacting protein 1 isoform 8
NM_001379348.1 NP_001366277.1 glutamate receptor-interacting protein 1 isoform 9
NM_001379349.1 NP_001366278.1 glutamate receptor-interacting protein 1 isoform 10
NM_001379351.1 NP_001366280.1 glutamate receptor-interacting protein 1 isoform 11
NM_021150.4 NP_066973.2 glutamate receptor-interacting protein 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11641419 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GRIP1 蛋白结构

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (54 - 133)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (152 - 235)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (259 - 333)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (477 - 558)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (575 - 655)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (674 - 751)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1006 - 1082)

  • 0
  • 200
  • 400
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  • 800
  • 1000
  • 1128 a.a.
蛋白主名 其他名称

glutamate receptor-interacting protein 1

GRIP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GRIP1 Q9Y3R0 IRF3 Homo sapiens Q14653
Pull Down
16362036
Intra GRIP1 Q9Y3R0 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra GRIP1 Q9Y3R0 PSMB9 Homo sapiens P28065
Y2H
16957778
Intra GRIP1 Q9Y3R0 PSMB9 Homo sapiens P28065
Pull Down
16957778
Intra GRIP1 Q9Y3R0 ESR1 Homo sapiens P03372
Pull Down
17545996
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fraser Syndrome 3

FRASRS3

Fraser Syndrome 1

Fraser Syndrome

Cryptophthalmos With Other Malformations

Cryptophthalmos Syndrome

FRASRS1

Cryptophthalmos-Syndactyly Syndrome

Fraser-Francois Syndrome

Cyclopism

Meyer-Schwickerath'S Syndrome

Ulrich-Feichtiger Syndrome

Cryptophthalmos Syndactyly Syndrome

Fraser'S Syndrome

Meyer-Schwickerath Syndrome

Ullrich-Feichtiger Syndrome

Cryptophthalmos
Renal Hypodysplasia/Aplasia 1

Renal Agenesis

Renal Adysplasia

Renal Aplasia

RHDA1

Hereditary Renal Aplasia

Hra

Hereditary Urogenital Adysplasia

Hypodysplasia/Aplasia, Renal, Type 1

Congenital Absence Of Kidneys Syndrome

Congenital Absence Of Kidney

Aplastic Kidney

Retinitis Pigmentosa 55

RP55

Retinitis Pigmentosa, Type 55

Chromosome 2q35 Duplication Syndrome

Syndactyly

Syndactyly Type 1

Sdty1

Zygodactyly

Syndactyly, Type I

Sd1

Syndactyly, Type 1, With Or Without Craniosynostosis

Symphalangism

Non-Syndromic Syndactyly

Symphalangy

Webbing Of Digits

Syndactyly, Type 1

Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Cri-Du-Chat Syndrome

5p Deletion Syndrome

5p Partial Monosomy Syndrome

Monosomy 5p

Cat Cry Syndrome

Chromosome 5p Deletion Syndrome

Cri Du Chat Syndrome

5p- Syndrome

5p Minus Syndrome

Chromosome 5p- Syndrome

Chromosome 5 Short Arm Deletion Syndrome

Chromosome 5p Deletion

Deletion 5p

Cri Du Chat

5p Partial Deletion Syndrome

Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus GRIP1 MGD MGI:1921303
Bos taurus GRIP1 VGNC VGNC:56205
Felis catus GRIP1 VGNC VGNC:62714
Rattus norvegicus GRIP1 RGD RGD:621667
Macaca mulatta GRIP1 VGNC VGNC:73195
Canis familiaris GRIP1 VGNC VGNC:41498
Others GRIP1 NCBI