2. Gene
  3. TNS4 - tensin 4 Gene

TNS4 - tensin 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：张力素 4

种属: Homo sapiens

同用名: CTEN; PP14434

基因 ID: 84951 | 基因类型: protein coding

关于 TNS4

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,475,834-40,501,623 (from NCBI)

This gene has 4 transcripts (splice variants), 171 orthologues and 1 paralogue. Biased expression in skin (RPKM 23.1), esophagus (RPKM 12.4) and 6 other tissues.

功能概要

预测启用肌动蛋白结合活性。参与蛋白质定位。位于粘着斑。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable actin binding activity. Involved in protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

TNS4 基因产物(1)

mRNA Protein Name
NM_032865.6 NP_116254.4 tensin-4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16273093 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein localization IDA
IDA: 通过直接分析推断
17190795 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in focal adhesion IDA
IDA: 通过直接分析推断
17190795 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNS4 蛋白结构

SH2

SH2: SH2 domain (449 - 538)

PTB

PTB: Phosphotyrosine-binding domain (582 - 705)

  • 0
  • 200
  • 400
  • 600
  • 715 a.a.
蛋白主名 其他名称

tensin-4

C terminal tensin like

TNS4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TNS4 Q8IZW8 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
Intra TNS4 Q8IZW8 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra TNS4 Q8IZW8 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
Intra TNS4 Q8IZW8 PPP3CA Homo sapiens Q08209-2
Y2H Prey Pooling
32296183
Intra TNS4 Q8IZW8 PPP3CA Homo sapiens Q08209-2
Y2H Array
32296183
Intra TNS4 Q8IZW8 KAZN Homo sapiens Q674X7-2
Y2H Prey Pooling
32296183
Intra TNS4 Q8IZW8 KAZN Homo sapiens Q674X7-2
Y2H Array
32296183
Intra TNS4 Q8IZW8 EGFR Homo sapiens P00533
Protein Array
16273093
Intra TNS4 Q8IZW8 PIH1D1 Homo sapiens Q9NWS0
Y2H Array
32296183
Intra TNS4 Q8IZW8 PIH1D1 Homo sapiens Q9NWS0
Y2H Prey Pooling
32296183
Intra TNS4 Q8IZW8 PIH1D1 Homo sapiens Q9NWS0
Validated Y2H
32296183
Intra TNS4 Q8IZW8 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra TNS4 Q8IZW8 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra TNS4 Q8IZW8 RABEP1 Homo sapiens Q15276
Y2H Prey Pooling
32296183
Intra TNS4 Q8IZW8 RABEP1 Homo sapiens Q15276
Y2H Array
32296183
Intra TNS4 Q8IZW8 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra TNS4 Q8IZW8 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra TNS4 Q8IZW8 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra TNS4 Q8IZW8 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra TNS4 Q8IZW8 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra TNS4 Q8IZW8 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra TNS4 Q8IZW8 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra TNS4 Q8IZW8 TRIM21 Homo sapiens P19474
Y2H Prey Pooling
32296183
Intra TNS4 Q8IZW8 TRIM21 Homo sapiens P19474
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Parotid Gland Cancer

Cancer Of Parotid Gland

Parotid Neoplasms

Malignant Neoplasm Of The Parotid

Malignant Tumor Of Parotid Gland

Parotid Cancer

Parotid Neoplasm

Parotid Gland Carcinoma

Cancer Of Parotid

Malignant Tumour Of Parotid Gland

Parotid Duct Cancer

Parotid Ductal Cancer

Parotid Glandular Cancer

Primary Malignant Neoplasm Of Parotid Gland
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14870 TNS4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TNS4 RGD RGD:1310402
Mus musculus TNS4 MGD MGI:2144377
Bos taurus TNS4 VGNC VGNC:36210
Felis catus TNS4 VGNC VGNC:66438
Canis familiaris TNS4 VGNC VGNC:47703
Macaca mulatta TNS4 VGNC VGNC:79432
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